Heart Regeneration in Zebrafish
- K. Poss, Lindsay G Wilson, M. Keating
- Biology, MedicineScience
- 13 December 2002
It is demonstrated histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection, showing that injury-induced cardiomyocyte proliferation in zebra fish can overcome scar formation, allowing cardiac muscle regeneration.
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
- K. Kikuchi, J. Holdway, K. Poss
- Biology, MedicineNature
- 25 March 2010
The results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations, which have implications for promoting regeneration of the injured human heart.
A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration
- Alexandra Lepilina, Ashley N. Coon, K. Poss
- Biology, MedicineCell
- 3 November 2006
Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
- Yoonsung Lee, S. Grill, Ángela Sánchez, Maureen Murphy-Ryan, K. Poss
- BiologyDevelopment
- 1 December 2005
It is demonstrated that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage, and the level of FgF signaling exhibits strict control over target gene expression, Blastemal proliferation and regenerative growth rate.
Heme oxygenase 1 is required for mammalian iron reutilization.
- K. Poss, S. Tonegawa
- BiologyProceedings of the National Academy of Sciences…
- 30 September 1997
Results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
The zebrafish is firmly established as a genetic model for the study of vertebrate blood development and its blood-forming system is characterized to provide a cellular context in which to study the genetics of hematopoiesis.
Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.
- K. Kikuchi, J. Holdway, K. Poss
- Biology, MedicineDevelopmental Cell
- 15 March 2011
Roles for Fgf signaling during zebrafish fin regeneration.
- K. Poss, J. Shen, M. Keating
- BiologyDevelopmental Biology
- 15 June 2000
It is found that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation and in distal blastemal tissue during regenerative outgrowth and that a specific inhibitor of Fgfr1 applied immediately following fin amputation blocks Blastema formation, without obvious effects on wound healing.
Reduced stress defense in heme oxygenase 1-deficient cells.
- K. Poss, S. Tonegawa
- BiologyProceedings of the National Academy of Sciences…
- 30 September 1997
In vitro and in vivo results provide genetic evidence that up-regulation of Hmox1 serves as an adaptive mechanism to protect cells from oxidative damage during stress.
Tales of regeneration in zebrafish
- K. Poss, M. Keating, A. Nechiporuk
- BiologyDevelopmental Dynamics
- 1 February 2003
Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration, and the remarkable ability of zebra fish to regenerate fins are shed light.
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