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Heart Regeneration in Zebrafish
TLDR
It is demonstrated histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection, showing that injury-induced cardiomyocyte proliferation in zebra fish can overcome scar formation, allowing cardiac muscle regeneration. Expand
A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration
TLDR
This work shows that regeneration proceeds through two coordinated stages following resection of the ventricular apex, and reveals injury responses by myocardial and epicardial tissues that collaborate in an Fgf-dependent manner to achieve cardiac regeneration. Expand
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
TLDR
The results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations, which have implications for promoting regeneration of the injured human heart. Expand
Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
TLDR
It is demonstrated that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage, and the level of FgF signaling exhibits strict control over target gene expression, Blastemal proliferation and regenerative growth rate. Expand
Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.
TLDR
It is shown that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2, which indicates key roles for endocardial and epicardial cells in targeting RA synthesis to damaged heart tissue and promoting cardiomyocyte proliferation. Expand
Roles for Fgf signaling during zebrafish fin regeneration.
TLDR
It is found that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation and in distal blastemal tissue during regenerative outgrowth and that a specific inhibitor of Fgfr1 applied immediately following fin amputation blocks Blastema formation, without obvious effects on wound healing. Expand
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
TLDR
The zebrafish is firmly established as a genetic model for the study of vertebrate blood development and its blood-forming system is characterized to provide a cellular context in which to study the genetics of hematopoiesis. Expand
Heme oxygenase 1 is required for mammalian iron reutilization.
  • K. Poss, S. Tonegawa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 30 September 1997
TLDR
Results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders. Expand
tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration
TLDR
It is found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration, indicating that natural epicardial fates are limited to non-myocardial cell types in zebrafish. Expand
Tales of regeneration in zebrafish
TLDR
Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration, and the remarkable ability of zebra fish to regenerate fins are shed light. Expand
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