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Proteomics in human disease: Cancer, heart and infectious diseases
In recent years, genomics has increased the understanding of many diseases. Proteomics is a rapidly growing research area that encompasses both genetic and environmental factors. The proteinExpand
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Characterization of myocardial protein composition in dilated cardiomyopathy by two-dimensional gel electrophoresis.
In order to identify alterations in the myocardial protein pattern that characterize dilated cardiomyopathy (DCM), we compared, by two-dimensional gel electrophoresis, right atrial protein patternsExpand
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A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection
An siRNA-based screen of host factors that influence infection by Chlamydia reveals the decoupling of the canonical Ras-ERK signaling pathway. Decoupling a MAPK Pathway Chlamydia trachomatis (Ctr) isExpand
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The construction of the World Wide Web‐accessible myocardial two‐dimensional gel electrophoresis protein database “HEART‐2DPAGE”: A practical approach
The construction of the two‐dimensional electrophoresis (2‐DE) gel protein database “HEART‐2DPAGE” for human heart proteins, accessible via the World Wide Web (WWW), is described. This databaseExpand
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Chamber‐specific expression of human myocardial proteins detected by two‐dimensional gel electrophoresis
High resolution two‐dimensional polyacrylamide gel electrophoresis (2‐D PAGE), followed by computer‐assisted image analysis (PDQUEST) was used to screen atrial and ventricular protein patterns forExpand
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Transgenic, Fluorescent Leishmania mexicana Allow Direct Analysis of the Proteome of Intracellular Amastigotes*S
Investigating the proteome of intracellular pathogens is often hampered by inadequate methodologies to purify the pathogen free of host cell material. This has also precluded direct proteome analysisExpand
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New algorithmic approaches to protein spot detection and pattern matching in two‐dimensional electrophoresis gel databases
Protein spot identification in two‐dimensional electrophoresis gels can be supported by the comparison of gel images accessible in different World Wide Web two‐dimensional electrophoresis (2‐DE) gelExpand
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Iterative data analysis is the key for exhaustive analysis of peptide mass fingerprints from proteins separated by two-dimensional electrophoresis
Peptide mass fingerprinting (PMF) is a powerful tool for identification of proteins separated by two-dimensional electrophoresis (2-DE). With the increase in sensitivity of peptide mass determinationExpand
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A two‐dimensional electrophoresis database of rat heart proteins
More than 3000 myocardial protein species of Wistar Kyoto rat, an important animal model, were separated by high‐resolution two‐dimensional gel electrophoresis (2‐DE) and characterized in terms ofExpand
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Representation of amino acid sequences as two‐dimensional point patterns
An algorithm for the representation of amino acid sequences as two‐dimensional point patterns (2‐D plot) is described. The algorithm is based on chaos game representation (CGR) for DNA sequences andExpand
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