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A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that… Expand
Polycomb complexes repress developmental regulators in murine embryonic stem cells
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability to differentiate into virtually all adult cell types are not well understood. Polycomb group (PcG) proteins… Expand
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Ectopic expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem (iPS)… Expand
Role of the Murine Reprogramming Factors in the Induction of Pluripotency
Induced pluripotent stem (iPS) cells can be obtained from fibroblasts upon expression of Oct4, Sox2, Klf4, and c-Myc. To understand how these factors induce pluripotency, we carried out genome-wide… Expand
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells
Transgenic and gene‐targeted mutant mice provide powerful tools for analysis of the cellular processes involved in early development and in the pathogenesis of many diseases. Here we describe a… Expand
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human ESCs and iPSCs suggests that,… Expand
Cooperative Binding of Transcription Factors Orchestrates Reprogramming
Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To gain a mechanistic understanding of their function, we mapped OSKM-binding, stage-specific transcription factors (TFs),… Expand
Generation of human induced pluripotent stem cells from dermal fibroblasts
- W. Lowry, L. Richter, +5 authors K. Plath
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 26 February 2008
The generation of patient-specific pluripotent stem cells has the potential to accelerate the implementation of stem cells for clinical treatment of degenerative diseases. Technologies including… Expand
Epigenetic reprogramming and induced pluripotency
The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte.… Expand
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.
Because of their somatic cell origin, human induced pluripotent stem cells (HiPSCs) are assumed to carry a normal diploid genome, and adaptive chromosomal aberrations have not been fully evaluated.… Expand