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A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
Polycomb complexes repress developmental regulators in murine embryonic stem cells
It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
Role of Histone H3 Lysine 27 Methylation in X Inactivation
It is demonstrated that transient recruitment of the Eed-Ezh2 complex to the inactive X chromosome (Xi) occurs during initiation of X inactivation in both extraembryonic and embryonic cells and is accompanied by H3-K27 methylation.
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Role of the Murine Reprogramming Factors in the Induction of Pluripotency
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells
A transgene integration strategy mediated by site‐specific recombination that allows establishment of multiple embryonic stem cell lines carrying tetracycline‐inducible genes targeted to a specific locus to assure predictable temporal and spatial expression in ES cells and mice is described.
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome
The data suggest a model for how Xist can integrate its two functions—localization to DNA and silencing of gene expression—to coat the entire X chromosome.
Generation of human induced pluripotent stem cells from dermal fibroblasts
- W. Lowry, L. Richter, K. Plath
- BiologyProceedings of the National Academy of Sciences
- 26 February 2008
Methods to use dermal fibroblasts easily obtained from an individual human to generate human induced pluripotent stem (iPS) cells by ectopic expression of the defined transcription factors KLF4, OCT4, SOX2, and C-MYC are described.
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
The results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state.