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SARS-CoV-2 Infection in Children
Investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years in SARS-CoV-2 Infection in Children.
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
The data implicate NETs and NET-mediated ECM remodeling as critical mediators of inflammation-induced awakening in mouse models of dormancy and propose that NETs awaken cancer by concentrating neutrophil proteases at the ECM protein laminin.
INTERACTIONS BETWEEN CHEMICAL AND CLIMATE STRESSORS: A ROLE FOR MECHANISTIC TOXICOLOGY IN ASSESSING CLIMATE CHANGE RISKS
- M. Hooper, G. Ankley, D. Cristol, Lindley A. Maryoung, Pamela D. Noyes, K. Pinkerton
- Environmental ScienceEnvironmental toxicology and chemistry
- 18 December 2012
This work employed adverse outcome pathways, constructs depicting linkages between mechanism-based molecular initiating events and impacts on individuals or populations, to assess how chemical- and climate-specific variables interact to lead to adverse outcomes.
Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential.
It is demonstrated that size and surface coating affect the cellular toxicity of Ag NPs as well as their acute versus sub-chronic lung injury potential.
Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect.
- A. Ghio, E. Hilborn, K. Pinkerton
- MedicineAmerican journal of respiratory and critical care…
- 1 December 2008
It is concluded that cigarette smoke particles alter iron homeostasis, both in the lung and systemically, as well as in healthy smokers and smoking patients with chronic obstructive pulmonary disease.
Receptor‐mediated tobacco toxicity: cooperation of the Ras/Raf‐1/MEK1/ERK and JAK‐2/STAT‐3 pathways downstream of a7 nicotinic receptor in oral keratinocytes
- J. Arredondo, A. Chernyavsky, D. Jolkovsky, K. Pinkerton, S. Grando
- Biology, MedicineFASEB journal : official publication of the…
- 1 October 2006
A novel mechanism of nicotine‐dependent nuclear transactivation of STAT‐3 identifies oral α7 nAChR as a promising molecular target to prevent, reverse, or retard tobacco‐related periodontal disease and progression of head and neck cancer by receptor inhibitors.
Morphometric characteristics of cells in the alveolar region of mammalian lungs.
- J. Crapo, S. Young, E. Fram, K. Pinkerton, B. Barry, R. Crapo
- Biology, MedicineThe American review of respiratory disease
- 14 May 2015
An overall striking similarity in characteristics of individual lung cells was found, and the distribution of cells in alveolar tissue was remarkably constant between species as was the average volume and surface area of most cell types.
MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity
MetaMapp graphs efficiently visualizes mass spectrometry based metabolomics datasets as network graphs in Cytoscape, and highlights metabolic alterations that can be associated with higher rate of pulmonary diseases and infections in children prenatally exposed to ETS.
The carcinogenicity of environmental tobacco smoke.
- H. Witschi, I. Espiritu, J. Peake, K. Wu, R. Maronpot, K. Pinkerton
- 1 March 1997
It was concluded that ETS is a pulmonary carcinogen in strain A/J mice and feeding of butylated hydroxytoluene during ETS exposure did not modulate lung tumor development.
Applying Definitions of “Asbestos” to Environmental and “Low-Dose” Exposure Levels and Health Effects, Particularly Malignant Mesothelioma
- B. Case, J. L. Abraham, G. Meeker, F. Pooley, K. Pinkerton
- MedicineJournal of toxicology and environmental health…
- 2 May 2011
This document reviews the current regulatory and mineralogical definitions of asbestos and how variability in these definitions has led to difficulties in the discussion and comparison of both experimental laboratory and human epidemiological studies for asbestos.