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Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease*
The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.
Microparticles: major transport vehicles for distinct microRNAs in circulation
Findings describe an interesting mechanism for transferring gene-regulatory function from MP-releasing cells to target cells via MP circulating in blood, which represents transport vehicles for large numbers of specific miRNAs, which have been associated with cardiovascular diseases.
CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1
It is demonstrated that CD40L interacts with the integrin Mac-1, which results in Mac- 1–dependent adhesion and migration of inflammatory cells as well as myeloperoxidase release in vitro.
New oral anticoagulant drugs in cardiovascular disease.
The clinical evaluation and pharmacological properties of novel oral anticoagulants in late and earlier stages of clinical development are discussed, thereby providing a critical analysis and an outlook on the future of oral antICOagulation in cardiovascular disease.
C-reactive protein: How conformational changes influence inflammatory properties
The novel understanding of the localized dissociation of circulating pentameric CRP to the distinctively pro-inflammatory monomericCRP allows for a new view on CRP in inflammatory reactions and further highlights mCRP and the pCRP dissociation process as a potential therapeutic target.
Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18).
A pharmacologically relevant property of heparin is described that may contribute to its benefits in clinical use and may directly modulate coagulation, inflammation, and cell proliferation.
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
The activation of coagulation (eg, as measured with plasma D-dimer) and thrombocytopenia have emerged as prognostic markers in COVID-19, and strategies to preventThrombotic complications are of critical importance.
Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation: In Vivo Proof of a Powerful Proinflammatory Mechanism and a New Anti-Inflammatory Strategy
In vivo evidence for a novel mechanism that localizes and aggravates inflammation via phospholipase A2–dependent dissociation of circulating pCRP to mCRP is provided and the inhibition of p CRP dissociation represents a promising, novel anti-inflammatory therapeutic strategy.
Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis: Validation of a Unique Noninvasive Method for Rapid and Sensitive Detection of Thrombi and Monitoring
It is demonstrated that glycoprotein IIb/IIIa–targeted MBs specifically bind to activated platelets in vitro and allow real-time molecular imaging of acute arterial thrombosis and monitoring of the success or failure of pharmacological thrombolysis in vivo.
Induction of Fibrinogen Binding and Platelet Aggregation as a Potential Intrinsic Property of Various Glycoprotein IIb/IIIa (IIbβ3) Inhibitors
The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP