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Folate bioavailability.
The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found inExpand
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Homocysteine, B-vitamins and CVD.
There is considerable interest in plasma homocysteine (tHcy) as a CVD risk factor. Although the secondary prevention trials published to date have been inconclusive in confirming a benefit ofExpand
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Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
BACKGROUND Mandatory folic acid fortification of food is effective in reducing neural tube defects and may even reduce stroke-related mortality, but it remains controversial because of concerns aboutExpand
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Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.
BACKGROUND Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trialsExpand
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The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet.
Folate intake is strongly influenced by various methods of cooking that can degrade the natural forms of the vitamin in foods. The aim of the present study was to determine the effect of differentExpand
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Emerging roles for folate and related B-vitamins in brain health across the lifecycle.
Nutrition plays a fundamental role in supporting the structural and functional development of the human brain from conception, throughout early infancy and extending into later life. A growing bodyExpand
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The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.
The natural folate derivative, 5-methyltetrahydrofolate ([6S]-5-MTHF), could be an option for supplementation and fortification but its bioavailability remains unclear. This study compared theExpand
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Folate, Related B Vitamins, and Homocysteine in Childhood and Adolescence: Potential Implications for Disease Risk in Later Life
OBJECTIVES. Folate and the metabolically related B vitamins are an important priority throughout life, but few studies have examined their status through childhood and adolescence. The aims of theExpand
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B-vitamins, homocysteine metabolism and CVD.
The present review focuses on the B-vitamins, i.e. folate, vitamin B12, vitamin B6 and riboflavin, that are involved in homocysteine metabolism. Homocysteine is a S-containing amino acid and itsExpand
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Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants.
Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia;Expand
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