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Assessment of exposure to butadiene in the process industry.
- M. Sorsa, S. Osterman-Golkar, K. Peltonen, S. Saarikoski, R. Sram
- Biology, Medicine
- 28 October 1996
Occupational exposure levels to 1,3-butadiene (BD) are variable but generally below 1 ppm in the European process industry. A preliminary analysis showed that hemoglobin adduct levels of butadiene… Expand
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides.
- H. L. Pérez, J. Lähdetie, +4 authors S. Osterman-Golkar
- Chemistry, Medicine
- Chemico-biological interactions
- 1 August 1997
Epoxybutanediol is one of the reactive metabolites of butadiene. It is formed via hydrolysis followed by oxidation of the primary metabolite of butadiene, epoxybutene, or via hydrolysis of… Expand
Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers.
The association of occupational exposure to 1,3-butadiene (BD) and induction of cytogenetic damage in peripheral lymphocytes was studied in 19 male workers from a monomer production unit and 19… Expand
Molecular cytogenetic analysis of buccal cells and lymphocytes from benzene-exposed workers.
Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases,… Expand
Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene.
Blood samples were collected twice (in 1993 and 1994) from 19 workers exposed to 1,3-butadiene and 19 matched controls. Three exposed and three control subjects were the same in 1993 and 1994.… Expand
Assessment of environmental and occupational exposures to butadiene as a model for risk estimation of petrochemical emissions.
- M. Sorsa, K. Peltonen, D. Anderson, N. Demopoulos, H. Neumann, S. Osterman-Golkar
- Biology, Medicine
1,3-Butadiene (BD) is an important industrial chemical and environmental contaminant, e.g. in urban air, traffic exhausts and tobacco smoke. It has been shown to be genotoxic in vitro and in vivo and… Expand
Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: a high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure.
- P. Koivisto, I. Kilpeläinen, I. Rasanen, I. Adler, F. Pacchierotti, K. Peltonen
- Medicine, Biology
- 1 July 1999
Butadiene (BD) is a high production volume chemical and is known to be tumorigenic in rodents. BD is metabolized to butadiene monoepoxide (BMO), diepoxybutane (DEB) and butadiene diolepoxide (BDE).… Expand
Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes.
The induction of sister chromatid exchanges (SCEs) by a 48-h treatment with 3,4-epoxybutane-1,2-diol (EBD), a metabolite of 1,3-butadiene, was studied in whole-blood lymphocyte cultures of 22 human… Expand
In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane.
Three metabolites of 1,3-butadiene, namely butadiene diolepoxide, butadiene monoepoxide and diepoxybutane, were tested in the bacterial mutation assay using Salmonella typhimurium strain TA100 with… Expand
32P-postlabelling/HPLC assay reveals an enantioselective adduct formation in N7 guanine residues in vivo after 1,3-butadiene inhalation exposure.
We have established a protocol that allows qualitative and quantitative determination of butadiene monoepoxide-DNA adducts formed as a result of inhalation exposure to 1,3-butadiene. We observed that… Expand