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Direct Comparison of Demyelinating Disease Induced by the Daniel's Strain and BeAn Strain of Theiler's Murine Encephalomyelitis Virus
Findings indicate that the diseases induced by DA or BeAn are distinct, and functional deficits as measured by Rotarod were more severe in DA infected versus BeAn infected mice.
Acceleration in the Rate of CNS Remyelination in Lysolecithin-Induced Demyelination
The hypothesis that spontaneous remyelination in the toxic nonimmune model of lysolecithin-induced demyelinating can be enhanced by manipulating the inflammatory response is supported, supporting the hypothesis that even in toxic nonprimary immune demYelination, manipulating theinflammatory response is a benefit in myelin repair.
CD4+ and CD8+ T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis
It is concluded that each T-cell subset makes a discrete and nonredundant contribution to protection from viral persistence and demyelination in resistant strains, in contrast, in susceptible strains, CD8+ T cells do not provide protection against chronic Demyelinating disease.
Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer.
An in vitro tumor cell/bone marrow coculture assay was developed and it was found that the type III IFN interleukin-28 (IL-28) was induced by viral activation of innate immune-sensing cells, acting as a key mediator of VSV-mediated virotherapy of B16ova melanomas.
Gamma Interferon Is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain following Early Intracranial Theiler's Murine Encephalomyelitis Virus Infection
In vitro analysis of virus-induced death in NSC34 cells and spinal motor neurons showed that IFN-γ exerted a neuroprotective effect in the absence of other aspects of the immune response, supporting the hypothesis that IFn-γ plays a critical role in protecting spinal cord neurons from persistent infection and death.
Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
Recognizing the presenting and immunopathological features of Kelch-like protein-11 immunoglobulin G seropositive (KLHL11 IgG+) patients may aid in early diagnosis and management of neurologic deficits and cancer associations.
Gamma interferon is critical for resistance to Theiler's virus-induced demyelination
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and
Chemokine Expression in the Central Nervous System of Mice with a Viral Disease Resembling Multiple Sclerosis: Roles of CD4+ and CD8+ T Cells and Viral Persistence
Surprisingly, the major determinant of chemokine expression was virus persistence: the factors of susceptible or resistant genotype, severity of neuropathology, and presence or absence of regulatory T cells exerted minimal effects.
Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.
In vivo administration of rIL-6 inhibited a murine CNS-demyelinating disease induced by a virus, suggesting that this IL may have application for the treatment of human MS.
The balance between persistent virus infection and immune cells determines demyelination.
The hypothesis that demyelination is the result of a balance between persistent virus infection and immune injury mediated by either CD4+ or CD8+ T cells is supported.