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Classification of primary progressive aphasia and its variants
This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for…
Understanding normal and impaired word reading: computational principles in quasi-regular domains.
Analysis of the ability of networks to reproduce data on acquired surface dyslexia support a view of the reading system that incorporates a graded division of labor between semantic and phonological processes, and contrasts in important ways with the standard dual-route account.
Where do you know what you know? The representation of semantic knowledge in the human brain
Mr M, a patient with semantic dementia — a neurodegenerative disease that is characterized by the gradual deterioration of semantic memory — was being driven through the countryside to visit a friend…
The neural and computational bases of semantic cognition
- M. L. Ralph, E. Jefferies, K. Patterson, T. Rogers
- Psychology, Computer ScienceNature Reviews Neuroscience
This Review summarizes key findings and issues arising from a decade of research into the neurocognitive and neurocomputational underpinnings of semantic cognition, leading to a new framework that is term controlled semantic cognition (CSC).
Structure and deterioration of semantic memory: a neuropsychological and computational investigation.
The authors present a parallel distributed processing implementation of this theory, in which semantic representations emerge from mechanisms that acquire the mappings between visual representations of objects and their verbal descriptions, to understand the structure of impaired performance in patients with selective and progressive impairments of conceptual knowledge.
Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy.
- J. Hodges, K. Patterson, S. Oxbury, E. Funnell
- PsychologyBrain : a journal of neurology
- 1 December 1992
The term semantic dementia is proposed, first coined by Snowden et al. (1989), to designate this clinical syndrome characterized by fluent dysphasia with severe anomia, reduced vocabulary and prominent impairment of single-word comprehension, progressing to a stage of virtually complete dissolution of the semantic components of language.
A voxel‐based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory
- C. Mummery, K. Patterson, C. Price, J. Ashburner, Richard S. J. Frackowiak, J. Hodges
- Biology, PsychologyAnnals of neurology
- 1 January 2000
It is confirmed that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region.
Non-verbal semantic impairment in semantic dementia
Semantic dementia: a unique clinicopathological syndrome
Focal cortical presentations of Alzheimer's disease.
Age at both onset and death was greater in the atypical AD cases than those with non-AD pathology, although survival was equivalent, and AD is a much commoner cause of focal cortical syndromes than previously recognised, particularly in PCA, PNFA and CBS, but rarely causes SD or bvFTD.