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Inparanoid: a comprehensive database of eukaryotic orthologs
TLDR
The Inparanoid eukaryotic ortholog database is a collection of pairwise ortholog groups between 17 whole genomes that were derived from Ensembl and UniProt and compared pairwise using Blast, followed by a clustering step using the InParanoid program. Expand
The DNA sequence of human chromosome 22
TLDR
The sequence of the euchromatic part of human chromosome 22 is reported, which consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome. Expand
Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma
TLDR
The breakpoints from translocations and rings in DP and its juvenile form, giant cell fibroblastoma (GCF) were characterised on the genomic and RNA level and deleted exon 1 of PDGFB and release this growth factor from its normal regulation. Expand
Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin
TLDR
The transient interfollicular NGAL expression during skin embryogenesis along with the induction of NGAL in adult parakeratotic epidermis suggests it play a role in epithelial differentiation pathways. Expand
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.
TLDR
It is concluded that the COLIA1/PDGFB fusion associated with DFSP contributes to tumor development through ectopic production of PDGF-BB and the formation of an autocrine loop, and suggests that PDGF receptors could be a target for pharmacological treatment of DFSP and giant cell fibroblastoma, e.g., through the use ofPDGF receptor kinase inhibitors such as CGP57148B. Expand
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.
TLDR
Growth-inhibitory effects of PDGF receptor antagonists on human DFSP- and GCF-derived tumor cells are demonstrated and autocrine PDGF receptors stimulation provides antiapoptotic signals contributing to the growth of these cells. Expand
Various regions within the alpha‐helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant‐cell fibroblastomas
TLDR
Characterization of COL1A1/PDGFB chimeric genes at the RNA and DNA sequence levels in a series of DFSPs and GCFs suggests that this exon does not encode for the mature growth factor and is important for the normal processing of the PDGFB polypeptide. Expand
Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population
TLDR
Two overlapping genes, SEEK1 and SPR1, are characterized and the cloning of its orthologs in mouse and pig is reported, both of which are expressed in normal and psoriasis skin. Expand
HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3.
TLDR
When comparing the frequencies of PSORS1C3 variants in a case-control material in the Swedish population, three single nucleotide polymorphisms displayed significant association with psoriasis, thus HLA-C remains the strongest associating factor in the region. Expand
C7, a novel nucleolar protein, is the mouse homologue of the Drosophila late puff product L82 and an isoform of human OXR1.
TLDR
Antibodies to recombinant C7 protein localized to nucleoli in a variety of cell types, suggesting that C7 may be involved in the formation or function of this important organelle. Expand
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