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Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis.
The Leishmania surface protease gp63 may contribute to parasite virulence by exerting a novel type of control over complement fixation by exploiting the opsonic properties of complement while avoiding its lytic effects. Expand
Sand Flies (Diptera: Phlebotominae) in Sanliurfa, Turkey Relationship of Phlebotomus sergenti with the Epidemic of Anthroponotic Cutaneous Leishmaniasis
Surprisingly, there was no apparent decrease in the relative abundance of this vector versus the other species, suggesting that factor(s) other than a change in the dynamics of sand fly populations precipitated the decline of the human leishmaniasis epidemic in Sanliurfa. Expand
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
The proteolytic activity of the metalloenzyme on the surface of these parasites may protect their membrane from cytolytic damages during their survival, differentiation, and multiplication in the phagolysosomes of macrophages. Expand
Diagnostic and prognostic value of K39 recombinant antigen in Indian leishmaniasis.
The results indicate that the K39 epitope is conserved in Indian strains of Leishmania donovani, the extremely high levels of K39 antibodies in both VL and PKDL suggest the application of rK39 for sensitive and specific serodiagnosis, and rK 39 ELISA is also valuable for prognostic evaluation of both diseases. Expand
Phagocytosis of Campylobacter jejuni and its intracellular survival in mononuclear phagocytes.
In vitro phagocytosis and intracellular survival of Campylobacter jejuni strain 2964 in mononuclear phagocytes were studied and it was indicated that C. je juni cells were readily phagcytized. Expand
Molecular determinants of Leishmania virulence.
Serodiagnosis of Asian leishmaniasis with a recombinant antigen from the repetitive domain of a Leishmania kinesin.
Antigen titrations with one positive serum revealed that rK39 was 25-fold more sensitive than Leishmania whole cell soluble lysates, and proved superior to 2 purified LeishMania antigens, a cytosolic protein (p36) and a membrane protein (gp63), for immunodiagnosis of visceral leishmaniasis. Expand
Monophyletic origin of beta-division proteobacterial endosymbionts and their coevolution with insect trypanosomatid protozoa Blastocrithidia culicis and Crithidia spp.
The evidence suggests that Blastocrithidia and Crithidia symbionts descend from a common ancestor, which had presumably entered an ancestral host and thence coevolved with it into different species. Expand
Heme biosynthesis in bacterium-protozoon symbioses: enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes.
It is concluded that the bacterial symbiotes augment a very limited heme biosynthetic capacity of host flagellates by supplying uroporphyrinogen I synthase and perhaps other enzymes preceding ferrochelatase in the heme BIOSynthetic chain. Expand
Heme requirement and acquisition by extracellular and intracellular stages of Leishmania mexicana amazonensis.
The inability to synthesize heme, a well known metabolic defect of trypanosomatid protozoa, accounts for their growth requirement for heme compounds in vitro. We now extend this finding to a pathogenExpand