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Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua.
Two new N-oxide araguspongines, (+)-araguspongine K and (+-arag Suspongine L, are described here, established on the basis of spectral analyses including (1)H-(15)N HMBC. Expand
Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer
Evidence is provided that Nar’s pro-apoptotic and chemo-sensitizing effects are mediated by perturbation of cell cycle, upregulation of pro-APoptotic genes and down-regulation of anti-ap Optic genes and inhibition of Pro-survival signaling pathways. Expand
Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors
Computer-derived syringic acid derivatives possess selective anti-mitogenic activity on human malignant melanoma cells that may be attributed to perturbation of cell cycle, induction of apoptosis and inhibition of various 26S proteasomal activities. Expand
Characterization of the major metabolite of sampangine in rats.
Evaluation of the antifungal and antibacterial activities of 2 showed it to have remarkable in vitro activity against Cryptococcus neoformans, and unstable, structurally uncharacterized minor metabolites were produced. Expand
New eudesmane sesquiterpenes from Plectranthus cylindraceus.
Three new eudesmane sesquiterpenes, plectranthone (1), desacetylplectranthone (2), isodeacetylplectranthone (3), and the three known flavonols pachypodol, casticin, and chrysosplenol D were isolatedExpand
Microbial transformation of sampangine.
Both metabolites 3 and 4 had significant in vitro activity against Cryptococcus neoformans but were inactive against Candida albicans and was inactive in vivo in a mouse model of cryptococcosis. Expand
Dihydroagarofuran alkaloid and triterpenes from Maytenus heterophylla and Maytenus arbutifolia.
The antimicrobially active EtOH extracts of Maytenus heterophylla yielded a new dihydroagarofuran alkaloid and beta-amyrin, maytenfolic acid showed moderate antimicrobial activity by inhibiting the growth of Candida albicans, Cryptococcus neoformans, Staphylococcus aureus and Pseudomonas aeruginosa. Expand
Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling
Results of this study are the first to reveal the potential of araguspongine C as an inhibitor to receptor tyrosine kinases resulting in the induction of autophagic cell death in breast cancer cells. Expand
Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans).
The two antimicrobial resorcinols malabaricone B [1] and malabaricone C [2] were isolated from mace, the dried seed covers of Myristica fragrans. Both compounds exhibited strong antifungal andExpand
Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors.
Marine-derived fungi have proven to be important sources of bioactive natural organohalides. The genus Penicillium is recognized as a rich source of chemically diverse bioactive secondaryExpand