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Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats.
The cortex of Eucommia ulmoides Oliver is widely used to treat kidney deficiency in traditional Chinese medicine. Its leaves have recently been reported to have anti-obesity properties in metabolicExpand
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Characterization of systemic and histologic injury after crush syndrome and intervals of reperfusion in a small animal model.
BACKGROUND Prolonged compression of limb muscles and subsequent decompression are important in the development of crush syndrome (CS). We applied a simple rubber tourniquet to rat hind limbs toExpand
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Topical application of Corchorus olitorius leaf extract ameliorates atopic dermatitis in NC/Nga mice
Abstract Background: Corchorus olitorius leaves are rich in antioxidants, fatty acids, minerals, vitamins and mucilaginous polysaccharides, and have been used as traditional folk medicine. In aExpand
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Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells.
Deoxycytidine kinase (dCK) is a rate-limiting enzyme for the activation of ara-C. It is responsible for the phosphorylation of ara-C which is widely used in the treatment of leukemia. We examined theExpand
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Impairment of Mycophenolate Mofetil Absorption by Calcium Polycarbophil
  • R. Kato, K. Ooi, +7 authors K. Ueno
  • Chemistry, Medicine
  • Journal of clinical pharmacology
  • 1 November 2002
The effect of calcium polycarbophil on the absorption of mycophenolate mofetil, an immunosuppressive agent, was evaluated in healthy subjects. In vitro studies were performed to further evaluate theExpand
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Skin disruption is associated with indomethacin‐induced small intestinal injury in mice
One mechanism by which non‐steroidal anti‐inflammatory drugs (NSAIDs) cause intestinal injury is by inducing matrix metalloproteinases (MMPs) that degrade and remodel the extracellular matrix. InExpand
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Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model
BACKGROUND Nitrite is an intrinsic signaling molecule with potential therapeutic implications in mammalian ischemia/reperfusion (I/R) injury of the heart, liver, and kidney. Although limb muscleExpand
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Acute lethal crush-injured rats can be successfully rescued by a single injection of high-dose dexamethasone through a pathway involving PI3K-Akt-eNOS signaling
BACKGROUND Crush syndrome (CS) is characterized by ischemia/reperfusion–induced rhabdomyolysis and the subsequent onset of systemic inflammation. CS is associated with a high mortality, even whenExpand
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Impairment of skin barrier function via cholinergic signal transduction in a dextran sulphate sodium‐induced colitis mouse model
Dry skin has been clinically associated with visceral diseases, including liver disease, as well as for our previously reported small intestinal injury mouse model, which have abnormalities in skinExpand
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Impaired skin barrier function in mice with colon carcinoma induced by azoxymethane and dextran sodium sulfate.
We have previously reported that impaired skin barrier function was induced by small intestinal injury in mice. Therefore, we postulated that other intestinal diseases might also influence skinExpand
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