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The selectivity of newly synthesized ergot derivatives to α1- and α2-adrenoceptors, D1- and D2-dopaminergic receptors, muscarinic acetylcholinoceptors and β-adrenoceptors
Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p on the affinity of partial agonists to the muscarinic receptor.
The actions of sodium nitroprusside and diltiazem on calcium-, potassium- and histamine-induced contractile responses in isolated rabbit basilar artery, aorta, taenia coli and tracheal smooth muscle.
- M. Ohashi, I. Takayanagi, A. Sekine, K. Okumura, H. Iwata
- Biology, MedicineJournal of pharmacobio-dynamics
- 1 July 1983
The actions of NaNP and diltiazem were considered to vary with the type of smooth muscle or the condition eliciting contraction, and their possible mechanisms were discussed in this paper.
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p and sodium ion on the affinity of dynorphin 1-13, nalorphine and nalorphine-7,8-oxide to kappa-opioid receptor.
Interaction of muscarinic drugs with their receptor.
Effects of aranidipine, a novel calcium channel blocker, on mechanical responses of the isolated rat portal vein: comparison with typical calcium channel blockers and potassium channel openers.
- K. Okumura, K. Ichihara, M. Nagasaka
- Biology, MedicineJournal of cardiovascular pharmacology
- 1 February 1997
ARA was found to be different from the typical Ca2+ channel blockers and in part similar to the K+ channel openers in inhibiting mechanical responses of isolated rat portal vein, suggesting that activation of K+ channels may in part in part be involved in the aranidipine-induced vasodilation.
Calcium entry blocking activities of MPC-1304 and of its enantiomers and metabolites.
Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.
- K. Ichihara, K. Okumura, H. Miyake
- Medicine, BiologyJournal of cardiovascular pharmacology
- 1 February 1998
The results suggest that, apart from antihypertensive efficiency, aranidipine may offer a therapeutic advantage by producing diuresis and natriuresis in hypertensive patients.
Cardiovascular Profile of MPC‐1304, a Novel Dihydropyridine Calcium Antagonist: Comparison with Other Calcium Antagonists
The cardiovascular profile of a novel calcium antagonist, MPC-1304 and its active metabolites were investigated in experimental animals in vitro and in vivo, and were compared with those of other…