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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan, which indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China.
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Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.

Autoimmune PAP had an incidence and prevalence higher than previously reported and was not strongly linked to smoking, occupational exposure, or other illnesses, and the disease severity score and biomarkers provide novel and potentially useful outcome measures in PAP.
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Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

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Phylogenetic and Geographic Relationships of Severe Fever With Thrombocytopenia Syndrome Virus in China, South Korea, and Japan.

Two clades of SFTSV may have evolved separately over time, and on rare occasions, the viruses were transmitted overseas to the region in which viruses of the other clade were prevalent.
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Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice.

Results strongly indicate a novel mechanism of HGF production by AMs, which are phagocytosing apoptotic neutrophils, and the pivotal role of AMs in the healing and repair of damaged pulmonary epithelium through the production of H GF.
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Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia

Bronchoalveolar lavage fluid levels of monocyte chemoattractant protein (MCP)-1/CC chemokine ligand-2 (CCL2), a potent macrophage-activating factor, were increased before the increases in the number of AM ingesting neutrophils and HGF levels in BAL fluid, and eventually aggravated lung tissue injury.
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Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines.

Clinical features and hematologic abnormalities associated with most DHF patients were thrombocytopenia and an increased fibrinolysis, but not disseminated intravascular coagulation.
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Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

Investigation of relationships of the presence of NETs and Cit-H3 with the existence of bacteria in tracheal aspirate, SIRS, diagnosis, WBC count, and concentrations of IL-8, TNF-α, cf-DNA, lactate, and HMGB1 found no significant relationships.
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Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases

The data support the view that persistent P. aeruginosa infection enhancesIL-8 production and IL-8-derived NCF activity, causing neutrophil accumulation in the airways and the progressive lung injuries observed in patients with CAD.
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Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells*

It is concluded that S. enteritidis FliC induces hBD-2 expression in Caco-2 cells via NF-κB activation and thus plays an important role in up-regulation of the innate immune response.
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