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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan
TLDR
This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan, which indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Expand
Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.
TLDR
Autoimmune PAP had an incidence and prevalence higher than previously reported and was not strongly linked to smoking, occupational exposure, or other illnesses, and the disease severity score and biomarkers provide novel and potentially useful outcome measures in PAP. Expand
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
TLDR
These global influenza-associated respiratory mortality estimates are higher than previously reported, suggesting that previous estimates might have underestimated disease burden. Expand
Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice.
TLDR
Results strongly indicate a novel mechanism of HGF production by AMs, which are phagocytosing apoptotic neutrophils, and the pivotal role of AMs in the healing and repair of damaged pulmonary epithelium through the production of H GF. Expand
Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia
TLDR
Bronchoalveolar lavage fluid levels of monocyte chemoattractant protein (MCP)-1/CC chemokine ligand-2 (CCL2), a potent macrophage-activating factor, were increased before the increases in the number of AM ingesting neutrophils and HGF levels in BAL fluid, and eventually aggravated lung tissue injury. Expand
Phylogenetic and Geographic Relationships of Severe Fever With Thrombocytopenia Syndrome Virus in China, South Korea, and Japan.
TLDR
Two clades of SFTSV may have evolved separately over time, and on rare occasions, the viruses were transmitted overseas to the region in which viruses of the other clade were prevalent. Expand
Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells*
TLDR
It is concluded that S. enteritidis FliC induces hBD-2 expression in Caco-2 cells via NF-κB activation and thus plays an important role in up-regulation of the innate immune response. Expand
The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis.
TLDR
The role of suilysin, a member of cholesterol-dependent cytolysins, in differential pathogenicity between ST1 and ST104 strains is investigated and it is suggested that it contributed to the higher bacterial density and enhanced inflammation in brain and increased mortality of meningitis in humans. Expand
Population-Based Study of Streptococcus suis Infection in Humans in Phayao Province in Northern Thailand
TLDR
The authors' data suggest a high incidence rate of S. suis infection in the general population in Phayao Province in 2010 and confirm a cluster of three cases in 31 human cases and food safety control should be strengthened especially for raw pork products in northern Thailand. Expand
Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.
TLDR
The data support the view that persistent P. aeruginosa infection enhancesIL-8 production and IL-8-derived NCF activity, causing neutrophil accumulation in the airways and the progressive lung injuries observed in patients with CAD. Expand
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