• Publications
  • Influence
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.
A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as
An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.
TLDR
A natural product from a basidiomycete, Ganoderma lucidum, is found that enhances this effect of LA in a special manner and is identified to be an ergosterol peroxide, 5,8-epidioxy-5alpha,8alpha-ergosta-6,22E-dien -3beta-ol by spectroscopic analyses.
Mammalian mitotic centromere‐associated kinesin (MCAK)
TLDR
It is concluded that clinically promising SQAGs have at least two different molecular targets, DNA polymerases and MCAK.
Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents.
TLDR
It is concluded that clinically promising SQAGs have at least two different molecular targets, DNA polymerases and MCAK.
A Minigenome Study of Hazara Nairovirus Genomic Promoters
TLDR
Using a HAZV minigenome system, the single-stranded nature of this region, as well as the potential of the following sequence to form dsRNA, is essential for reporter gene expression and the sequence of the PE2 ds RNA appears to be equally important for promoter activity.
Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.
TLDR
Fomitellic acid A and ursolic acid prevented the growth of NUGC cancer cells, with LD(50) values of 38 and 30 microM respectively, suggesting the DNA-binding sites of both enzymes, which compete for the inhibitors, might be very similar.
...
1
2
3
4
5
...