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Microglia-specific localisation of a novel calcium binding protein, Iba1.
Recently it has been shown that mRNA of Iba1 (ionized calcium binding adaptor molecule 1), which was a novel calcium binding protein cDNA-cloned by our group, is specifically expressed in microgliaExpand
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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Microglia, brain immune cells, engage in the clearance of dead cells or dangerous debris, which is crucial to the maintenance of brain functions. When a neighbouring cell is injured, microglia moveExpand
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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage.
We successfully isolated a rat cDNA clone encoding a novel EF hand protein with a molecular weight of about 17 kDa and designated this gene iba1 (ionized calcium binding adapter molecule 1). TheExpand
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Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through Gi/o-Coupled P2Y Receptors
The initial microglial responses that occur after brain injury and in various neurological diseases are characterized by microglial accumulation in the affected sites of brain that results from theExpand
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Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.
Ionized calcium binding adaptor molecule 1, Iba1, is an EF hand calcium binding protein whose expression is restricted to macrophages/microglia. In this study, Iba1 was shown to colocalize withExpand
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Involvement of P2X4 and P2Y12 receptors in ATP‐induced microglial chemotaxis
We previously reported that extracellular ATP induces membrane ruffling and chemotaxis of microglia and suggested that their induction is mediated by the Gi/o‐protein coupled P2Y12 receptor (P2Y12R).Expand
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Mechanisms underlying extracellular ATP‐evoked interleukin‐6 release in mouse microglial cell line, MG‐5
Microglia play various important roles in the CNS via the synthesis of cytokines. The ATP‐evoked production of interleukin‐6 (IL‐6) and its intracellular signals were examined using a mouseExpand
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Iba1 is an actin-cross-linking protein in macrophages/microglia.
Iba1 is a 17-kDa EF hand protein that is specifically expressed in macrophages/microglia and is upregulated during the activation of these cells. When exposed to macrophage colony-stimulating factorExpand
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Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors
Microglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microgliaExpand
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Akt activation is involved in P2Y12 receptor‐mediated chemotaxis of microglia
Microglia play a variety of significant roles in the central nervous system (CNS), and in one of those roles they undergo morphological change in response to neural injury and migrate to the injuredExpand
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