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Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria
TLDR
A sensitive and simultaneous quantification method was developed for membrane proteins that constructed a quantitative atlas of membrane transporter proteins at the blood–brain barrier, liver and kidney in mouse. Expand
Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction.
TLDR
Examination of the Blast Bank samples from 22 patients with MDS, 31 with AML, and 8 with chronic myeloid leukemia confirmed the highly selective expression of the Dlk gene, which could be the first candidate molecule to differentiate MDS from AML. Expand
Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells
TLDR
Compared with DNA microarray the expression profiles of 3456 genes in the purified HSC-like fractions that had been isolated from 13 CML patients and healthy volunteers suggest that microarray analysis with background-matched samples is an efficient approach to identify molecular events underlying the stage progression in CML. Expand
Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line.
TLDR
Changes in the redox state caused by antioxidants such as ascorbic acid can overcome resistance to imatinib via inhibition of Nrf2-mediated gene expression. Expand
Cancer gene therapy using mesenchymal stem cells
TLDR
The potential of MSCs as cellular vehicles for targeted cancer therapy and the molecular mechanisms underlying MSC accumulation at tumor sites are reviewed. Expand
Sak Serine-Threonine Kinase Acts as an Effector of Tec Tyrosine Kinase*
TLDR
The data collectively supports a novel role of Sak acting in the PTK-mediated signaling pathway, and internal deletion of the PEST sequences led to the stabilization of Sak proteins, and expression of these mutants acted suppressive to cell growth. Expand
Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2
TLDR
Cellular heme level plays an important role in determining the sensitivity of cells to imatinib and certain other anti‐leukemia drugs and that the effect of heme may be mediated via its ability to upregulate Nrf2 activity. Expand
Mechanisms of resistance to azacitidine in human leukemia cell lines.
TLDR
This study generated two azacitidine-resistant cell lines, THP-1/AR and HL60/AR, and studied genetic disparities between them and their corresponding parental lines, providing new insights into azacItidine resistance and establishes models useful in developing effective strategies to overcome it. Expand
Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study
TLDR
AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo- HSCT, although the differences were not statistically significant. Expand
Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks.
TLDR
Information about the rank order of transporter protein expression will be useful to predict what transporter(s) are likely or unlikely to influence the permeability of various compounds across monolayers of Caco-2 cells, which are widely used in drug development studies. Expand
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