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Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.
  • R. Thompson, K. Ohlsson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 September 1986
The affinity of the inhibitor for leukocyte elastase is very high, suggesting a functional role for the protein in preventingElastase-mediated damage to oral and possibly other mucosal tissues. Expand
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The regional dimension is highlighted in this context because most renewable energy projects are carried out on local scale, based on the regional resource potential and vulnerability to climate change is very much determined by regional land use and the location of energy infrastructure. Expand
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
It is reported that a specific interleukin-1 receptor antagonist reduces the lethality of endotoxin-induced shock in rabbits, indicating that interleuko-1 does indeed play an important part in endotoxin shock. Expand
Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa.
In vitro, elastolytic activity of bronchial secretions from patients with cystic fibrosis was significantly inhibited by eglin C and an oxidation-resistant variant of alpha 1-PI, both compounds currently produced by recombinant DNA technology. Expand
Human cystatin C. role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase.
It is argued that the N-terminal cystatin C interaction with cathepsin B is physiologically important and hence that leucocyte elastase could have a function as a regulator of extracellular cysteine-proteinase inhibitory activity at sites of inflammation. Expand
Increasing Levels of Leukocyte-Derived Inflammatory Mediators in Plasma and cAMP in Platelets during Follow-Up after Acute Cerebral Ischemia
Plasma NGAL and sTNFR-1 and intraplatelet AMP increase after acute cerebral ischemia, indicating chronic inflammatory activity and endothelial activation and plasma sTN FR-1 levels are related to intraplatelets cGMP levels. Expand
Leukocyte Activation: Relation to Cardiovascular Mortality after Cerebrovascular Ischemia
In patients with acute cerebral ischemia, plasma markers of leukocyte activation were significant predictors of long-term cardiovascular mortality, which may indicate an important role of activated leukocytes in the progression of these diseases. Expand
Radioimmunological determination and characterization of cathodal trypsin-like immunoreactivity in normal human plasma.
The normally circulating cathodal trypsin-like immunoreactivity is shown to consist mainly of cathodale trypsInogen, which is a type of Trypsin that is insoluble in DFP. Expand
Leukocyte activation in atherosclerosis: correlation with risk factors.
It is demonstrated that, in subjects with asymptomatic early atherosclerosis, the plasma levels of markers of systemic leukocyte activation were correlated with age and blood pressure, and were higher in smokers and hypertensives. Expand
Protease inhibitors in acute human pancreatitis. Correlation between biochemical changes and clinical course.
In accordance with earlier findings, activation of both the complement and kinin systems seems possible in both blood and peritoneal fluid at the low alpha 2-M concentrations found in severe attacks. Expand