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The Human‐Specific Action of Intermedilysin, a Homolog of Streptolysin O, Is Dictated by Domain 4 of the Protein
Absorption assays with erythrocyte membranes from various animals, competitive inhibition with domain 4 of intermedilysin and liposome‐binding assays of streptolysin O and intermedallysin indicated that cell membrane binding is the human‐specific step of interMedilysin action, that the host cell membrane‐binding site is located within domain 4 in common with other members of the family and that the receptor for this toxin is not cholesterol. Expand
Histone‐like DNA binding protein of Streptococcus intermedius induces the expression of pro‐inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways
Results indicate that Si‐HLP can trigger a cascade of events that induce pro‐inflammatory responses via ERK1/2 and JNK signal pathways, and suggest that bacterial HLP may contribute to the activation of host innate immunity during bacterial infection. Expand
Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.
The heme pocket of CYP3A4 is very flexible and is able to interact with various types of substrate and be bound by two selected ligand accessible regions. Expand
Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis.
Results indicated that the configuration of 4-hydroxyl group of brefeldin A plays a key role in the cytotoxicity and induction of apoptosis. Expand
Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius
Results indicate that surface‐bound ILY on S. intermedius is an important factor for invasion of human cells by this bacterium and that secretion of ILY within host cells is essential for subsequent host cell death. Expand
Rapid identification of Streptococcus intermedius by PCR with the ily gene as a species marker gene.
An accurate PCR identification system with the ily gene as a species marker is developed, applicable in direct rapid PCR with whole bacterial cells and TaKaRa Z-Taq, a highly efficient DNA polymerase, as the template and DNA amplification enzyme, respectively. Expand
TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.
A comprehensive evaluation of these agents with respect to protein tyrosine kinase inhibition, mitochondrial inhibition, antitumor activity, and hepatotoxicity demonstrates that PTK inhibitors TX-1123 and TX-1925 are more promising candidates for antitumors agents than tyrphostin AG17. Expand
Analysis of structural features of bis-quaternary ammonium antimicrobial agents 4,4′-(α,ω-Polymethylenedithio)bis (1-alkylpyridinium iodide)s using computational simulation
Abstract The bis-quaternary ammonium compounds (QACs) consisted of two identical alkylpyridinium rings and a bridge structure linking the rings to each other. The QACs have a methylene bridge exceptExpand
Characterization of recombinant Streptococcus mitis‐derived human platelet aggregation factor
Characterization of recombinant Streptococcus mitis‐derived human platelet aggregation factor and its role in cell reprograming is described. Expand
Effect of molecular chirality and side chain bulkiness on angiogenesis of haloacetylcarbamoyl-2-nitroimidazole compounds.
The designed and synthesized antiangiogenetic TX agent (TX-1898, -1900), and analyzed their structural features, which exhibited significant antiANGiogenic activity. Expand