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The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans
TLDR
It is suggested that fexofenadine is a substrate of OATP2B1, and the transport function of O ATP2 B1 is subject to the genotype of SLCO 2B1 c.1457C>T and apple juice.
Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH
Omeprazole is mainly metabolized in the liver by CYP2C19, a genetically determined enzyme, whereas rabeprazole is mainly reduced non‐enzymatically and partially metabolized by CYP2C19. The
Effect of Genetic Differences in Omeprazole Metabolism on Cure Rates for Helicobacter pylori Infection and Peptic Ulcer
TLDR
Whether differences in CYP2C19 genotype status would affect cure rates for H. pylori infection and peptic ulcer in patients who received dual therapy with omeprazole and amoxicillin is prospectively studied.
Pharmacogenomics‐based Tailored Versus Standard Therapeutic Regimen for Eradication of H. pylori
TLDR
The pharmacogenomics‐based tailored treatment for H. pylori infection allowed a higher eradication rate by the initial treatment without an increase of the final per‐patient cost for successful eradication, but the precise cost‐effectiveness of this strategy remains to be determined.
Pharmacogenomics of proton pump inhibitors.
TLDR
The CYP2C19 genotyping test is a useful tool for deciding on the optimal treatment regimen using a PPI, including a dual (PPI plus antibiotic) or a triple ( PPI plus two antibiotics) therapy.
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans.
Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin.
TLDR
The genotyping test of CYP2C19 appears to be a clinically useful tool for the optimal dual treatment with rabeprazole plus amoxicillin for Helicobacter pylori infection as well as for hetEM and PM patients.
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers
TLDR
It is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows.
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole
TLDR
Whether therapeutic effects of lansoprazole on gastroesophageal reflux disease (GERD) depended on the CYP2C19 genotype status in relation to the grade of GERD is assessed.
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