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Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a liver transporter that mediates the uptake of a variety of structurally diverse compounds, and has a high affinity for cardiac
Sulfation of environmental estrogens by cytosolic human sulfotransferases.
TLDR
The phenolic endocrine-disrupting chemicals, bisphenol A (BPA), 4-n-nonylphenol (NP), and 4-t-octyl phenol (t-OP), were used as substrates to investigate the possible participation of human SULTs in their metabolism for excretion.
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.
TLDR
Oatp1b2-null mice display altered basic physiology and markedly decreased hepatic uptake/toxicity of phalloidin and microcystin-LR, a blue-green algae toxin, and are useful in elucidating the role of Oatp 1b2 and its human orthologs OATP1B1/1B3 in hepatics uptake and systemic disposition of toxic chemicals and therapeutic drugs.
Organic anion–transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2‐null mice
TLDR
Oatp1b2 has a major role in the hepatic uptake of unconjugated BAs, as indicated by the concentrations of BAs in plasma, liver, and bile compared with wild‐type (WT) mice.
Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3
TLDR
The inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT3A3 are investigated.
FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS
TLDR
Results indicate that TAM-DNA adducts are formed via O-sulfonation, not O-acetylation, of α-hydroxylated TAM and its metabolites.
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