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Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors.
To clarify preventive effects of n-3 polyunsaturated fatty acids (PUFAs) against colorectal carcinogenesis, we performed a dietary intervention in patients polypectomized for colorectal… Expand
Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats.
BACKGROUND & AIMS Long-Evans cinnamon (LEC) rats are an animal model of Wilson's disease. This study investigated whether intrahepatic transplantation of normal hepatocytes can prevent Wilson's… Expand
Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers
- T. Saitoh, Y. Fukushima, +7 authors S. Ohkawa
- Alimentary pharmacology & therapeutics
- 1 October 2002
Aim : To investigate the inhibitory effects on gastric acid secretion of three proton pump inhibitors, omeprazole, lansoprazole and rabeprazole, using a three‐way crossover design in healthy… Expand
Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.
3-Monochloropropane-1,2-diol (3-MCPD) is regarded as a rat renal and testicular carcinogen and has been classified as a possible human carcinogen (group 2B) by International Agency for Research on… Expand
Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat.
- Saeko Onami, Y. Cho, +6 authors K. Ogawa
- Chemistry, Medicine
- Regulatory toxicology and pharmacology : RTP
- 1 December 2015
IARC has classified glycidol and 3-monochloropropane-1,2-diol (3-MCPD) as group 2A and 2B, respectively. Their esters are generated in foodstuffs during processing and there are concerns that they… Expand
Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats.
BACKGROUND & AIMS Pancreatic stellate cells have some similarities to hepatic stellate cells and an intrinsic renin-angiotensin system is present in the pancreas and is enhanced in acute pancreatitis… Expand
The herbal medicine Inchin‐ko‐to inhibits liver cell apoptosis induced by transforming growth factor β1
Transforming growth factor β1 (TGF‐β1) is reported to play an important role in the induction of liver cell apoptosis. In this report, we demonstrate that TGF‐β1 induces apoptosis in a rat Morris… Expand
Volatile Fatty Acids, Lactic Acid, and pH in the Stools of Breast‐Fed and Bottle‐Fed Infants
- K. Ogawa, Ricardo A. Ben, S. Pons, María Isabel L. Paolo, L. B. Fernández
- Journal of pediatric gastroenterology and…
- 1 October 1992
Summary We measured fecal pH, volatile fatty acids (VFA), and lactic acid concentrations in 67 healthy infants ranging in age from 1 to 5 months. The babies were divided into five groups according to… Expand
Size-dependent acute toxicity of silver nanoparticles in mice
- Y. Cho, Yasuko Mizuta, Jun-ichi Akagi, T. Toyoda, Mizuki Sone, K. Ogawa
- Chemistry, Medicine
- Journal of toxicologic pathology
- 19 November 2017
In this study, we aimed to evaluate changes in the acute toxicity of intraperitoneally administered silver nanoparticles (AgNPs) of varying sizes in BALB/c mice. Seven-week-old female BALB/c mice… Expand
Addition of Metronidazole to Rabeprazole‐Amoxicillin‐Clarithromycin Regimen for Helicobacter pylori Infection Provides an Excellent Cure Rate with Five‐Day Therapy
Background. New triple therapy for eradication of Helicobacter pylori based on a proton pump inhibitor (PPI) provides a cure rate of approximately 90% with few adverse effects. Recently, a PPI‐based… Expand