K. Odaguchi

Publications21
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Citations194
Highly Influential Citations0
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Adrenocortical stimulation by a cholecystokinin preparation in the rat.
Affinity of 18,19-dihydroxydeoxycorticosterone and 18-hydroxy-19-nor-deoxycorticosterone to aldosterone receptor and their mineralocorticoid activity.
TLDR
18-OH-19-nor-DOC bound to the receptor with an affinity similar to that of 18-hydroxydeoxycorticosterone (18- OH-DOC) or spironolactone, and its sodium retaining activity was 0.04 times as great as that of DOC and similar to those of 18,OH-DOC.
Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives.
TLDR
Three steroid derivatives having the delta 11-pregnane skeleton with a 17-gamma-spirolactone function were synthesized and 3-(17 beta-hydroxy-3-oxoandrosta-1,4,6,11-tetraen-17 alpha-yl)propionic acid gamma-lactone exhibited good aldosterone antagonist activity in an in vivo assay.
Aldosterone antagonists. 1. Synthesis and biological activities of 11 beta,18-epoxypregnane derivatives.
TLDR
Several steroid derivatives having the 11 beta,18-epoxypregnane skeleton, 7, 8, 19, 20, 21, and 31, were synthesized to evaluate their antialdosterone activity and 31 possessed fairly strong binding affinity for the cytoplasmic mineralocorticoid receptor of rat kidney and exhibited good aldosterone antagonist activity in an in vivo assay.
ALDOSTERONE ANTAGONISTS. 1. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 11β,18-EPOXYPREGNANE DERIVATIVES
Effect of caerulein on plasma corticosterone concentration in the rat.
Suppressive effect of pentagastrin on pituitary-adrenocortical secretion.
TLDR
In in vitro incubation of rat pituitary tissue the addition of pentagastrin elicited a suppressive effect on the ACTH release from the tissue into the medium, and it was suggested that gastrin-like peptide might control the secretion of ACTH.
Insignificance of pituitary for growth of androgen-dependent mouse mammary tumor.
Stimulation of corticosterone production by atrial natriuretic polypeptide in hypophysectomized rats.
Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats.
TLDR
Sustained increase of gastric PGE2 by BHB could be responsible for protection against indomethacin-induced gastric mucosal lesions and that BHB is a suitable anti-ulcer agent for NSAIDs without compromising their anti-inflammatory effects.
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