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Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.
OBJECTIVE In men, hypoandrogenism is associated with features of the metabolic syndrome, but the role of sex hormones in the pathogenesis of the metabolic syndrome and diabetes is not well… Expand
High Stored Iron Levels Are Associated With Excess Risk of Myocardial Infarction in Eastern Finnish Men
- J. Salonen, K. Nyyssönen, H. Korpela, J. Tuomilehto, R. Seppänen, R. Salonen
- 1 September 1992
BackgroundIron can induce lipid peroxidation in vitro and in vivo in humans and has promoted ischemic myocardial injury in experimental animals. We tested the hypothesis that high serum ferritin… Expand
Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men.
BACKGROUND Even though previous studies have suggested an association between high fish intake and reduced coronary heart disease (CHD) mortality, men in Eastern Finland, who have a high fish intake,… Expand
Relation between iron stores and non-insulin dependent diabetes in men: case-control study
Non-insulin dependent diabetes mellitus is a common complication of diseases of iron overload such as haemochromatosis; 53-80% of patients with haemochromatosis develop diabetes.1 The development of… Expand
Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study.
BACKGROUND Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial. We assessed the predictive value of serum uric acid… Expand
The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study.
- D. Laaksonen, L. Niskanen, +4 authors J. Salonen
- The Journal of clinical endocrinology and…
- 1 February 2005
In men, hypoandrogenism is associated with features of the metabolic syndrome. It is not known whether men with the metabolic syndrome are at a higher risk of developing hypogonadism. We therefore… Expand
C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men
Aims/hypothesisLow-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We… Expand
Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.
- J. Mursu, S. Voutilainen, +5 authors J. Salonen
- Chemistry, Medicine
- Free radical biology & medicine
- 1 November 2004
Cocoa powder is rich in polyphenols and, thus, may contribute to the reduction of lipid peroxidation. Our aim was to study the effects of long-term ingestion of chocolate, with differing amounts of… Expand
Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries.
BACKGROUND The atherosclerotic progression-reducing effect of LDL cholesterol (LDL-C) lowering has been established in subjects with severe atherosclerotic disease but not in persons with elevated… Expand
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis
Abstract. Salonen JT, Nyyssönen K, Salonen R, Lakka H‐M, Kaikkonen J, Porkkala‐Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, tuomainen T‐P, Valkonen V‐P, Ristonmaa U (University of… Expand