• Publications
  • Influence
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci.
Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may pointExpand
  • 220
  • 12
  • PDF
Genetic and environmental contributions to cardiovascular disease risk in American Indians: the strong heart family study.
The aims of the Strong Heart Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in American Indians and to map and identify genes for CVD susceptibility. TheExpand
  • 162
  • 11
Exploring the genetic basis of chronic periodontitis: a genome-wide association study
Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of aExpand
  • 178
  • 10
  • PDF
Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal
Liver fibrosis is a highly dynamic process in which multiple genes interact with environmental factors. Recent human epidemiologic studies have identified possible polymorphisms in a number ofExpand
  • 332
  • 9
Genome-wide Association Study of Periodontal Pathogen Colonization
Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated withExpand
  • 108
  • 9
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
Background The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. Methods and Findings We conducted an association study of body massExpand
  • 145
  • 9
  • PDF
Association of adolescent obesity with risk of severe obesity in adulthood.
CONTEXT Although the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been studied over time to determine whether they develop severe obesity inExpand
  • 384
  • 8
  • PDF
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: An Atherosclerosis Risk in Communities (ARIC) Study
Endothelial dysfunction contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids in the vasculature and regulates endothelialExpand
  • 147
  • 8
  • PDF
A Bivariate Genome-Wide Approach to Metabolic Syndrome
OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes andExpand
  • 176
  • 7
  • PDF
Prospective Analysis of Mannose-Binding Lectin Genotypes and Coronary Artery Disease in American Indians: The Strong Heart Study
Background—Mannose-binding lectin (MBL) is a circulating immune factor responsible for opsonization of pathogens and directly activating complement. Common variations in the MBL gene are responsibleExpand
  • 98
  • 7