• Publications
  • Influence
Detection of JC virus DNA sequences in colorectal cancers in Japan
JC virus (JCV), a ubiquitous polyoma virus that commonly infects humans, was first identified as the etiologic agent for the fetal demyelinating disease, progressive multifocal leukoencephalopathy.Expand
  • 64
  • 10
Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia.
Chronic inflammation is a common theme in a variety of disease pathways, including autoimmune diseases. The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitisExpand
  • 123
  • 6
Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma.
BACKGROUND Gastric carcinoma is still a major leading cause of cancer death in East Asia. Since angiogenesis is a necessary condition for invasion and metastasis, its regulation is of essentialExpand
  • 245
  • 5
Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray
Aim: To investigate the pathobiological features of intestinal and diffuse-type gastric carcinomas in the Japanese population. Methods: The expression of fragile histine triad (FHIT), phosphatase andExpand
  • 115
  • 4
Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt’s lymphoma cells
Purpose: Epstein-Barr virus (EBV) is associated with the development of several lymphoid and epithelial malignancies, including Burkitt’s lymphoma. The EBV latent protein, EBV Nuclear Antigen 1Expand
  • 64
  • 4
The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression
Cadmium (Cd) is a highly hepatotoxic heavy metal, which is widely dispersed in the environment. Acute Cd hepatotoxicity has been well studied in experimental animals; however, effects of prolongedExpand
  • 66
  • 3
Disrupted galectin‐3 causes non‐alcoholic fatty liver disease in male mice
Galectin‐3, a β‐galactoside‐binding animal lectin, is a multifunctional protein. Previous studies have suggested that galectin‐3 may play an important role in inflammatory responses. Non‐alcoholicExpand
  • 51
  • 3
Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung
In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the materialExpand
  • 9
  • 3
  • PDF
Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression
PurposePim-3, a member of the proto-oncogene Pim family with serine/threonine kinase activity was aberrantly expressed in cancerous lesions of endoderm-derived organs such as liver, pancreas, andExpand
  • 53
  • 2
Cytoplasmic Fine Granular Expression of 8-hydroxydeoxyguanosine Reflects Early Mitochondrial Oxidative DNA Damage in Nonalcoholic Fatty Liver Disease
To clarify the possible role of oxidative stress in hepatocytes in nonalcoholic fatty liver disease, the hepatic expression of 8-hydroxydeoxyguanosine (8-OHdG), a good marker of oxidative DNA damage,Expand
  • 40
  • 2