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[Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain].
Kyotorphin is an analgesic neuropeptide isolated from the bovine brain in 1979. Further studies showed that kyotorphin produces an analgesia through an increased release of met-enkephalin in theExpand
Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats.
Previously, a significant decrease in the trough plasma-concentration of valproic acid (VPA) owing to the concomitant administration of panipenem (PAPM)/betamipron, a carbapenem antibiotic, inExpand
Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord.
We isolated a potent inhibitor of enkephalin-degrading enzymes from bovine spinal cord and determined its amino-acid sequence and inhibitory activity toward enkephalin-degrading enzymes. This newExpand
Identification of dipeptidyl peptidase III in human neutrophils.
We have found activity of dipeptidyl peptidase (DPP) III, one of the most important enkephalin-degrading enzymes in the central nervous system, in human neutrophils. HPLC analysis of the peptideExpand
Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.
It is possible that enkephalins are involved in the pain-modulating mechanism in the spinal cord. Enkephalins, however, are short-lived, being rapidly degraded by various endogenous enzymes. ManyExpand
[Study of a new endogenous inhibitor of enkephalin-degrading enzymes; pharmacological function and metabolism of spinorphin].
Spinorphin, a potent inhibitor of enkephalin degrading enzyme isolated from the bovine spinal cord, produces a dose-related inhibition of electrically evoked contractions of both MVD (mouse vasExpand
[Spinorphin, a new inhibitor of enkephalin-degrading enzymes derived from the bovine spinal cord].
We have isolated a potent inhibitor of enkephalin-degrading enzymes from the bovine spinal cord, and determined its amino-acid sequence and inhibitory activity against enkephalin-degrading enzymes.Expand
[Antihypertensive and diuretic effects of indapamide in normotensive and hypertensive rats (author's transl)].
Antihypertensive and diuretic actions of indapamide (SE-1520) were investigated in rats and compared with those of trichlormethiazide (TCMT). In normotensive rats, indapamide in a dose of 100 mg/kgExpand
[General pharmacology of (2"R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic].
General pharmacology of (2"R)-4'-O-tetrahydropyranyladriamycin hydrochloride (THP) was studied in experimental animals. Intravenous administration of THP showed no significant effect on theExpand
新抗腫瘍性抗生物質 (2R)-4'-O-Tetrahydropyranyladriamycinの一般薬理作用
General pharmacology of (2"R)-4'-O-tetrahydropyranyladriamycin hydrochloride (THP) was studied in experimental animals. Intravenous administration of THP showed no significant effect on theExpand
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