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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducibleExpand
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Mechanisms of neural plasticity following brain injury
Brain insults cause rapid cell death, and a disruption of functional circuits, in the affected regions. As the injured tissue recovers from events associated with cell death, regenerative processesExpand
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GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion
GPR56 (also known as TM7XN1) is a newly discovered orphan G-protein-coupled receptor (GPCR) of the secretin family that has a role in the development of neural progenitor cells and has been linked toExpand
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Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)
Regulation of N‐methyl‐d‐aspartate (NMDA) receptors is critical for the normal functioning of the central nervous system. There must be precise mechanisms to allow for changes in receptor functionExpand
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Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia*
Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNAExpand
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Neuronal Activity Induction of the Stathmin-Like Gene RB3 in the Rat Hippocampus: Possible Role in Neuronal Plasticity
Synaptic activity induces a rapid transcriptional response that is essential for the establishment of long-term neuronal plasticity. Using a differential cloning technique, we have identified a geneExpand
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Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia
Basic helix–loop–helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular stresses and environmental factors suchExpand
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Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach*
  • L. Gan, S. Ye, +11 authors R. Urfer
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 13 February 2004
Alzheimer's disease is a progressive neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. Activated microglia are foundExpand
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Discoidin Domain Receptor-1a (DDR1a) Promotes Glioma Cell Invasion and Adhesion in Association with Matrix Metalloproteinase-2
SummaryInvasion of glioma cells involves the attachment of invading tumor cells to extracellular matrix (ECM), disruption of ECM components, and subsequent cell penetration into adjacent brainExpand
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Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia‐induced gene expression patterns, and
In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large‐scale cDNA array analysis ofExpand
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