K. Nguyen

Publications106
h-index41
Citations8,026
Highly Influential Citations400
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Natural killer cells in antiviral defense: function and regulation by innate cytokines.
TLDR
A detailed picture is developing of particular innate cytokines activating NK cell responses and their consorted effects in providing unique endogenous milieus promoting downstream adaptive responses, most beneficial in defense against viral infections.
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Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection1
TLDR
The results define the coordinated interactions between the cytokines IFN-αβ, IL-12, and IL-15 for activation of protective NK cell responses during viral infections, and emphasize these factors’ nonredundant functions under in vivo physiological conditions.
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Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection
TLDR
It is shown that IFN-α/β activate STAT4 directly and that this is required forIFN-γ production during viral infections of mice, in concert with T cell receptor–derived signals.
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Alpha/Beta Interferon Protects Adult Mice from Fatal Sindbis Virus Infection and Is an Important Determinant of Cell and Tissue Tropism
TLDR
IFN-α/β protects the normal adult host from viral infection by rapidly conferring an antiviral state on otherwise permissive cell types, both locally and systemically.
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Cutting Edge: Inhibitory Functions of the Killer Cell Lectin-Like Receptor G1 Molecule During the Activation of Mouse NK Cells1
TLDR
It is demonstrated that both pathogenic and nonpathogenic in vivo activation of NK cells induces the expression of KLRG1 on their cell surface, which inhibits both cytokine production and NK cell-mediated cytotoxicity and illustrates the crucial role played by K LRG1 during the termination of mouse NK cell activation.
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SAP controls T cell responses to virus and terminal differentiation of TH2 cells
TLDR
The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes.
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Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome
ABSTRACT Laboratory strains of viruses may contain cell culture-adaptive mutations which result in significant quantitative and qualitative alterations in pathogenesis compared to natural virus…
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Diagnostic and Phylogenetic Utility of the rDNA Internal Transcribed Spacer Sequences of Steinernema.
TLDR
The results support the taxonomic utility of the ITS region to diagnose nematode species of the genus Steinernema, and all sampled taxa show evidence (in the form of numerous autapomorphic characters) of lineage independence, however, the ITS area appears to be phylogenetically informative only for closely related sister species.
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Entomopathogenic Nematodes: Systematics, Phylogeny and Bacterial Symbionts
The volume deals with history, morphology, taxonomy, and systematics of entomopathogenic nematodes (EPN) in the families Steinernematidae and Heterorhabditidae, molecular methods and bacteria…
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Entomopathogenic nematodes (Steinernematidae and Heterorhabditidae) from the southwestern parts of South Africa
TLDR
Soil samples were collected in the southwestern parts of South Africa to obtain entomopathogenic nematodes of the families Steinernema and Heterorhabditis, where they parasitise different life stages of various soil-inhabiting insects.
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