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Diversity of the Human Intestinal Microbial Flora
TLDR
A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered. Expand
Environmental Genome Shotgun Sequencing of the Sargasso Sea
TLDR
Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity. Expand
The complete genome sequence of the gastric pathogen Helicobacter pylori
TLDR
Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, and consistent with its restricted niche, it has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Expand
Genome sequence of the human malaria parasite Plasmodium falciparum
TLDR
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria. Expand
Structure, Function and Diversity of the Healthy Human Microbiome
TLDR
The Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far, finding the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. Expand
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
TLDR
The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen. Expand
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.
Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes. The bacterium also has considerable potentialExpand
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
TLDR
A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species. Expand
Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis
TLDR
The complete genome sequence of Enterococcus faecalisV583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA, which probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci. Expand
A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes
TLDR
It is evident from this analysis that CRISPR/cas loci are larger, more complex, and more heterogeneous than previously appreciated. Expand
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