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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify aExpand
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Myelination and support of axonal integrity by glia
  • K. Nave
  • Biology, Medicine
  • Nature
  • 11 November 2010
The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.Expand
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Axonal regulation of myelination by neuregulin 1
  • K. Nave, J. Salzer
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • 1 October 2006
Neuregulins comprise a family of epidermal growth factor-like ligands that interact with ErbB receptor tyrosine kinases to control many aspects of neural development. One of the most dramatic effectsExpand
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Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
‘Tomacula’ and myelin outfoldings are striking neuropathological features of a diverse group of inherited demyelinating neuropathies. Whereas the underlying genetic defects are well known, theExpand
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The role of myelin and oligodendrocytes in axonal energy metabolism
In vertebrates, the myelination of long axons by oligodendrocytes and Schwann cells enables rapid impulse propagation. However, myelin sheaths are not only passive insulators. Oligodendrocytes areExpand
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NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons
Mutations affecting peripheral nervous system development in Drosophila and mouse indicate that neural differentiation depends on the coordinated expression of cell type-specific bHLH proteins. WeExpand
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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
Intrathymic expression of tissue-specific self antigens may be involved in immunological tolerance and protection from autoimmune disease. We have analyzed the role of T-cell tolerance to proteolipidExpand
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Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
The integrity of central and peripheral nervous system myelin is affected in numerous lipid metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily high level ofExpand
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Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. The predominant subtype, CMT-1A, accounts for more than 50% of all cases and is associated with an interstitial chromosomalExpand
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Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
The protease β‐secretase 1 (Bace1) was identified through its critical role in production of amyloid‐β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 isExpand
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