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An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy.
A novel mutation in the M2 domain of the CHRNA4 gene in a Norwegian family is described, which shows a significantly lower calcium permeability that, at the cellular level, may correspond to a loss of function.
Clinical Research Physical Exercise in Outpatients with Epilepsy
  • K. Nakken
  • Medicine, Psychology
  • 1 May 1999
To compare the exercise habits in a sample of adult outpatients with epilepsy with those of a general population of the same age and sex and to study physical exercise as a seizure precipitant and the risk of sustaining seizure‐related injuries while exercising.
Seizure‐Related Injuries in Multihandicapped Patients with Therapy‐Resistant Epilepsy
It is concluded that even persons with refractory epilepsy should be encouraged to lead active lives, and seizure‐induced injury risk was slight, and precautionary measures can be taken.
Effect of Physical Training on Aerobic Capacity, Seizure Occurrence, and Serum Level of Antiepileptic Drugs in Adults with Epilepsy
The average seizure frequency during the 4‐week exercise period was compared with 2 preexercise and 2 postexercise weeks and there was no significant difference, but there was considerable variation among patients.
Bone loss associated with use of antiepileptic drugs
Clinicians are recommended to promote osteoprotective behavior among epilepsy patients; that is, sunlight exposure and weight-bearing exercise as well as avoidance of risk factors such as bone-depleting drugs other than AEDs, smoking and heavy alcohol consumption.
Seizure control and treatment in pregnancy
The majority of patients with epilepsy maintain seizure control during pregnancy, and the apparently higher risk of seizures among women treated with ox carbazepine and the more frequent increases in drug load in the oxcarbazepines and lamotrigine cohorts prompts further studies on relationships with pharmacokinetic changes.
Physical Exercise in Women with Intractable Epilepsy
It is believed that 15 weeks is too short a time to establish a life‐style change and that continued physical exercise for these patients requires a well‐organized and supportive program, requiring experienced and dedicated instructors.