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Analysis of newly synthesized Bruch's membrane proteoglycans.
Bruch's membrane may provide a selective filtration barrier for nutrients coming from the choriocapillaris to the outer retina. Because proteoglycans have been shown to have structural and filtrationExpand
Defective processing of keratan sulfate in macular corneal dystrophy.
Macular corneal dystrophy is a human genetic disorder characterized by corneal opacities that arise, in part, from a failure to synthesize mature keratan sulfate proteoglycans. The macromolecules inExpand
Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities
Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking through the type 1 sphingosine 1-phosphate receptor (S1P1) and participates in many pathological conditions, including autoimmuneExpand
Stimulation of Glucose Uptake in Muscle Cells by Prolonged Treatment with Scriptide, a Histone Deacetylase Inhibitor
Glucose incorporation is regulated mainly by GLUT4 in skeletal muscles. Here we report that treatment of L6 myotubes with scriptide, a hydroxamic acid-based histone deacetylase (HDAC) inhibitor,Expand
Structure of oligosaccharides and the linkage region between keratan sulfate and the core protein on proteoglycans from monkey cornea.
Structural analyses were performed on the intact glycopeptides and on the linkage region oligosaccharide-peptides derived from the keratan sulfate proteoglycan from monkey cornea (Nakazawa, K.,Expand
Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis.
Sphingosine 1-phosphate receptor type 1 (S1P(1)) was shown to be essential for vascular maturation during embryonic development and it has been demonstrated that substantial crosstalk exists betweenExpand
Keratan sulfate synthesis by corneal stromal cells within three-dimensional collagen gel cultures.
The corneal stromal cells from 2-day-old chicks were cultured on plastic dishes or within three-dimensional collagen gel in the presence or absence of growth factor (EGF, bFGF, PDGF, TGF-beta 1, orExpand
Purification of keratan sulfate proteoglycan from monkey cornea.
An explant culture of 15 cynomolgus monkey corneas was incubated with [35S]sulfate and [2-3H]mannose as labeling precursors. A 4 M guanidine HCl extract of the corneal stromas was prepared andExpand
Corneal Proteoglycan Biosynthesis and Macular Corneal Dystrophy
Proteoglycans are constitutive components of all connective tissues. They consist of a protein core containing covalently attached glycosaminoglycan and oligosaccharide side chains. Antibodies haveExpand
Synthesis and secretion of biologically active mouse Interferon-β using a Bacillus subtilis α-amylase secretion vector
Mouse interferon-beta (IFN-beta) cDNA, whose signal sequence had been removed by BAL 31 digestion, was introduced into a Bacillus subtilis secretion vector constructed by using the promoter andExpand