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The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

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Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and Japanese (n = 100) subjects with the 8‐hour urinary metaboUc ratio of…
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Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

A new mutation is identified in Japanese poor metabolizers, consisting of a guanine to adenine mutation at position 636 of exon 4 of CYP2C19, which creates a premature stop codon.
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Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs.

The pharmacokinetics of troglitazone (CAS 97322-87-7, CS-045), a new oral antidiabetic drug for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), were investigated in rats, mice and…
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Excessive salt or cholesterol intake alters the balance among endothelium-derived factors released from renal arteries in spontaneously hypertensive rats.

The findings indicate that in the renal artery of SHRs, ACh causes production of a sufficient amount of nitric oxide (NO), together with a relaxing factor resembling endothelium-derived hyperpolarizing factors (EDHFs) and also endothelia-derived contracting factors ( EDCFs), probably prostaglandin H2.
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2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor.

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Chemical restraint of African lions (Panthera leo) with medetomidine-ketamine.

Atipamezole, at four times the preceding dose of medetomidine, provided a smooth recovery and animals were able to stand up 17-61 min after its injection, and side effects were limited to vomiting after walking in 3 of 5 lions.
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Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy.

In this review, the molecular mechanisms of diabetic retinopathy and nephropathy are discussed, especially focusing on advanced glycation end products (AGEs) and their receptor (RAGE) system.
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Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.

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Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice.

Water extract of Cordyceps sinensis showed a strong cytotoxicity against LLC and B16 cells, while cordycepin (3'-deoxyadenosine), an active component of WECS, was not cytotoxic against these cells.
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