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Polymorphisms of DNA repair genes are associated with renal cell carcinoma.
DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity and may influence an individual's susceptibility to carcinogenesis. Single nucleotide polymorphisms (SNPs) ofExpand
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Heat Shock Transcription Factor 1 Is Involved in Quality-Control Mechanisms in Male Germ Cells1
Abstract Quality-control mechanisms in spermatogenesis are important to eliminate injured or abnormal cells, thereby protecting the organism from abnormal development in the next generation. TheExpand
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Nitric Oxide Promotes Germ Cell Necrosis in the Delayed Phase after Experimental Testicular Torsion of Rat
Abstract The purpose of this study is to determine whether inducible nitric oxide synthase (iNOS) is involved in the pathogenesis of testicular ischemia-reperfusion (I/R) injury in association withExpand
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Bax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder cancer.
OBJECTIVE In this study, locally advanced bladder cancer was treated by radiation combined with cisplatin therapy and a retrospective analysis was conducted to predict the clinical response toExpand
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Biological Characteristics in Bladder Cancer Depend on the Type of Genetic Instability
Purpose: Malignant tumors show an inherent genetic instability that can be classified as microsatellite instability (MSI) or chromosomal instability (CIN). To elucidate the differences in biologicalExpand
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Gain of 5p15.33 Is Associated with Progression of Bladder Cancer
Objective: To search for a biological marker to distinguish low-risk from high-risk bladder cancer indicating disease progression. Methods: The whole genome-wide copy numbers were screened in 18Expand
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Mass Spectrometry Analysis of the Native Protein Complex Containing Actinin-4 in Prostate Cancer Cells*S
Actinin-4 was originally identified as an actin-binding protein associated with cell motility and cancer invasion and metastasis. However, actinin-4 forms complexes with a large number of differentExpand
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Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
It has been shown that the matrix metalloproteinase (MMP)-1 promoter polymorphism 1G/2G is associated with an increased risk of developing various cancers including renal cell carcinoma (RCC), and isExpand
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Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer.
BUBR1, a mitotic checkpoint protein, is a key component of the mitotic spindle checkpoint machinery. Defective BUBR1 has been proposed to contribute to chromosomal instability (CIN). To elucidate theExpand
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Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma.
BACKGROUND Ras association domain family 1A (RASSF1A) is a tumor suppressor that regulates the cell cycle, apoptosis, and microtubule stability. The association between the methylation levels ofExpand
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