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Heat Shock Transcription Factor 1 Is Involved in Quality-Control Mechanisms in Male Germ Cells1
TLDR
It is found that heat shock proteins are not induced in male germ cells in response to thermal stress, although heat shock transcription factor 1 (HSF1) is activated, and it is demonstrated that HSF1 has two opposite roles inmale germ cells independent of the activation of heat shock genes.
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Polymorphisms of DNA repair genes are associated with renal cell carcinoma.
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Gain of 5p15.33 Is Associated with Progression of Bladder Cancer
TLDR
The data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may become a potential biomarker identifying high-risk patients with disease progression in bladder cancer.
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Mass Spectrometry Analysis of the Native Protein Complex Containing Actinin-4 in Prostate Cancer Cells*S
TLDR
The decreased expression of actinin-4 protein in prostate cancer cells may cause aberrations in the intracellular trafficking of various cell surface molecules and contribute to carcinogenesis.
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Nitric Oxide Promotes Germ Cell Necrosis in the Delayed Phase after Experimental Testicular Torsion of Rat
TLDR
Inducible NOS inhibition combined with calpain inhibition may improve impaired spermatogenesis after testicular torsion and promote α-fodrin proteolysis, which is closely associated with necrosis.
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Bax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder cancer.
TLDR
The results of this study suggest that the combined assessment of Bcl-2 and Bax protein expression may be used to predict a clinical response to CRT based on the Bax/B cl-2 ratio determined before therapy.
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Biological Characteristics in Bladder Cancer Depend on the Type of Genetic Instability
TLDR
There are differences in the biological characteristics of the two types of genetic instability in bladder cancer between microsatellite instability and chromosomal instability, according to the expression of the mismatch repair proteins and p53 proteins.
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Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
TLDR
The frequency of the 2G-G haplotype of MMP-1 1G/2G and M MP-3 Glu45Lys (G/A) polymorphisms was significantly higher in the patients than in the controls, suggesting that this haplotypes of Mmp-1 andMMP-3 variants may be associated with the risk of developing RCC.
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Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer.
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Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma.
TLDR
Results indicate that quantitative promoter methylation levels of the RASSF1A gene may be a useful marker to predict the prognosis of CCRCC.
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