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- Publications
- Influence
Polymorphisms of DNA repair genes are associated with renal cell carcinoma.
- H. Hirata, Y. Hinoda, +10 authors R. Dahiya
- Biology, Medicine
- Biochemical and biophysical research…
- 21 April 2006
DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity and may influence an individual's susceptibility to carcinogenesis. Single nucleotide polymorphisms (SNPs) of… Expand
Heat Shock Transcription Factor 1 Is Involved in Quality-Control Mechanisms in Male Germ Cells1
- Hanae Izu, S. Inouye, M. Fujimoto, K. Shiraishi, K. Naito, A. Nakai
- Biology, Medicine
- Biology of reproduction
- 2004
Abstract Quality-control mechanisms in spermatogenesis are important to eliminate injured or abnormal cells, thereby protecting the organism from abnormal development in the next generation. The… Expand
Nitric Oxide Promotes Germ Cell Necrosis in the Delayed Phase after Experimental Testicular Torsion of Rat
- K. Shiraishi, K. Naito, K. Yoshida
- Biology, Medicine
- Biology of reproduction
- 1 August 2001
Abstract The purpose of this study is to determine whether inducible nitric oxide synthase (iNOS) is involved in the pathogenesis of testicular ischemia-reperfusion (I/R) injury in association with… Expand
Bax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder cancer.
- H. Matsumoto, T. Wada, K. Fukunaga, S. Yoshihiro, H. Matsuyama, K. Naito
- Medicine
- Japanese journal of clinical oncology
- 1 March 2004
OBJECTIVE
In this study, locally advanced bladder cancer was treated by radiation combined with cisplatin therapy and a retrospective analysis was conducted to predict the clinical response to… Expand
Biological Characteristics in Bladder Cancer Depend on the Type of Genetic Instability
- Y. Yamamoto, H. Matsuyama, +6 authors K. Sasaki
- Biology, Medicine
- Clinical Cancer Research
- 1 May 2006
Purpose: Malignant tumors show an inherent genetic instability that can be classified as microsatellite instability (MSI) or chromosomal instability (CIN). To elucidate the differences in biological… Expand
Gain of 5p15.33 Is Associated with Progression of Bladder Cancer
- Y. Yamamoto, Y. Chochi, +7 authors K. Sasaki
- Medicine
- Oncology
- 1 November 2007
Objective: To search for a biological marker to distinguish low-risk from high-risk bladder cancer indicating disease progression. Methods: The whole genome-wide copy numbers were screened in 18… Expand
Mass Spectrometry Analysis of the Native Protein Complex Containing Actinin-4 in Prostate Cancer Cells*S
Actinin-4 was originally identified as an actin-binding protein associated with cell motility and cancer invasion and metastasis. However, actinin-4 forms complexes with a large number of different… Expand
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
- H. Hirata, N. Okayama, +6 authors Y. Hinoda
- Biology, Medicine
- Carcinogenesis
- 1 December 2004
It has been shown that the matrix metalloproteinase (MMP)-1 promoter polymorphism 1G/2G is associated with an increased risk of developing various cancers including renal cell carcinoma (RCC), and is… Expand
Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer.
- Y. Yamamoto, H. Matsuyama, +7 authors K. Sasaki
- Biology, Medicine
- Cancer genetics and cytogenetics
- 1 April 2007
BUBR1, a mitotic checkpoint protein, is a key component of the mitotic spindle checkpoint machinery. Defective BUBR1 has been proposed to contribute to chromosomal instability (CIN). To elucidate the… Expand
Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma.
- Y. Kawai, S. Sakano, +6 authors Y. Hinoda
- Medicine
- Annals of oncology : official journal of the…
- 1 August 2010
BACKGROUND
Ras association domain family 1A (RASSF1A) is a tumor suppressor that regulates the cell cycle, apoptosis, and microtubule stability. The association between the methylation levels of… Expand
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