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A new Rac target POSH is an SH3‐containing scaffold protein involved in the JNK and NF‐κB signalling pathways
TLDR
It is proposed that POSH acts as a scaffold protein and contributes to Rac‐induced signal transduction pathways leading to diverse gene transcriptional changes.
Filament Formation of MSF-A, a Mammalian Septin, in Human Mammary Epithelial Cells Depends on Interactions with Microtubules*
TLDR
Findings of immunocytochemical and biochemical characterization of a mammalian septin, MSF-A, strongly suggest that septin filaments may interact not only with actin filaments but also with microtubule networks and that GTPase activity is not indispensable to incorporation of MSf-A into septin Filaments.
The MAP kinase kinase kinase MLK2 co‐localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
TLDR
Yeast two‐hybrid analysis and in vitro dot‐blots show that MLK2 and MLK3 interact with the activated (GTP‐bound) forms of Rac and Cdc42, with a slight preference for Rac, suggesting a potential link between stress activation and motor protein function.
Autophosphorylation of a Newly Identified Site of Aurora-B Is Indispensable for Cytokinesis*
TLDR
It is reported here that human Aurora-B is phosphorylated at Thr-232 through interaction with the inner centromere protein (INCENP) in vivo, indicating that the phosphorylation of Thr-230 is an essential regulatory mechanism for Aurora- B activation.
Biochemical and Cell Biological Analyses of a Mammalian Septin Complex, Sept7/9b/11*
TLDR
Results suggest that septin filament structures may be affected by interactions with other septins included in the septin complex.
Coronary smooth muscle differentiation from proepicardial cells requires rhoA-mediated actin reorganization and p160 rho-kinase activity.
TLDR
Important roles for rhoA-RhoK signaling in molecular pathways controlling cytoskeletal reorganization, SRF-dependent transcription, and cell survival that are required to produce CoSMCs from proepicardial cells are found.
Functions of a Rho-specific Guanine Nucleotide Exchange Factor in Neurite Retraction
TLDR
Molecular dissection analyses revealed that a proline-rich motif C-terminally adjacent to DH/PH domain is essential for plasma membrane localization of KIAA0380 and cortical actin reorganization followed by cell rounding, and suggest that KIAa0380 plays an important role in neurite retraction through Rho-dependent signaling.
Aurora-B Regulates the Cleavage Furrow-specific Vimentin Phosphorylation in the Cytokinetic Process*
TLDR
It is shown that vimentin-Ser-72 phosphorylation occurred specifically at the border of the Aurora-B-localized area from anaphase to telophase and controls vimentIn filament segregation in cytokinetic process.
Balance between Activities of Rho Kinase and Type 1 Protein Phosphatase Modulates Turnover of Phosphorylation and Dynamics of Desmin/Vimentin Filaments*
TLDR
The results indicate that Rho kinase is activated not only in mitotic cells but also interphase ones, and phosphorylates intermediate filament proteins, although the apparent phosphorylation level is diminished to an undetectable level due to the constitutive action of type 1 protein phosphatase.
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