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YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666.
A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666 and inhibited ADP-induced platelets aggregation in human platelet-rich plasma with an IC50 value below 0.6 microM by blocking the P2Y1 receptor-signal transduction pathway.
YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological…
- K. Nagai, K. Kamigiri, Ken-ichi Suzuki
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 February 2003
Two novel antibiotics were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica and exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains.
YM-254890 analogues, novel cyclic depsipeptides with Galpha(q/11) inhibitory activity from Chromobacterium sp. QS3666.
Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
- Y. Hayakawa, Kahori Sasaki, H. Adachi, K. Furihata, K. Nagai, K. Shin‐ya
- Biology, ChemistryThe Journal of Antibiotics
Thioviridamide showed cytotoxicity selectively against 3Y1 rat fibroblasts transformed with adenovirus oncogenes and significant numbers of Ad12-3Y1 cells treated with thiovirIDamide contained condensed chromatin and fragmented nuclei, indicating that thiovIRidamide induced apoptosis.
Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.
Studies on the distribution of alkalophilic and alkali-tolerant soil fungi I
Ability to grow under alkaline conditions, as well as under acidic conditions, was common in many Acremonium species, suggesting the use of alkaline medium facilitates the isolation of alkalophilic soil fungi.
Byelyankacin: A Novel Melanogenesis Inhibitor Produced by Enterobacter sp. B20
A novel melanogenesis inhibitor, byelyankacin, was isolated from the fermentation broth of a bacterial strain and determined as (E)-4-(2-isocyanovinyl)phenyl α-L-rhamnopyranoside on the basis of spectroscopic data.
Carteramine A, an inhibitor of neutrophil chemotaxis, from the marine sponge Stylissa carteri.
YM-215343, a novel antifungal compound from Phoma sp. QN04621.
YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus and showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.
YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge II. Structure elucidation.
Two new antibacterial substances that have activity against drug-resistant bacteria produced by Bacillus cereus QN03323 are revealed, containing the cyclic thiopeptides containing thiazole and pyridine moieties, and several unusual amino acids.