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- Publications
- Influence
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
- K. Nader, G. Schafe, J. E. L. Doux
- Chemistry, Medicine
- Nature
- 17 August 2000
‘New’ memories are initially labile and sensitive to disruption before being consolidated into stable long-term memories. Much evidence indicates that this consolidation involves the synthesis of new… Expand
Memory traces unbound
- K. Nader
- Chemistry, Medicine
- Trends in Neurosciences
- 1 February 2003
The idea that new memories are initially 'labile' and sensitive to disruption before becoming permanently stored in the wiring of the brain has been dogma for >100 years. Recently, we have revisited… Expand
Cellular and Systems Reconsolidation in the Hippocampus
- J. Debiec, Joseph E LeDoux, K. Nader
- Psychology, Medicine
- Neuron
- 24 October 2002
Cellular theories of memory consolidation posit that new memories require new protein synthesis in order to be stored. Systems consolidation theories posit that the hippocampus has a time-limited… Expand
A single standard for memory: the case for reconsolidation
- K. Nader, Oliver Hardt
- Psychology, Medicine
- Nature Reviews Neuroscience
- 1 March 2009
Consolidated memories can re-enter states of transient instability following reactivation, from which they must again stabilize in order to persist, contradicting the previously dominant view that… Expand
Reply — reconsolidation: The labile nature of consolidation theory
- K. Nader, G. Schafe, Joseph E LeDoux
- Psychology, Medicine
- Nature Reviews Neuroscience
- 1 December 2000
'Consolidation' has been used to describe distinct but related processes. In considering the implications of our recent findings on the lability of reactivated fear memories, we view consolidation… Expand
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory
- M. Costa-Mattioli, D. Gobert, +11 authors N. Sonenberg
- Biology, Medicine
- Cell
- 6 April 2007
The late phase of long-term potentiation (LTP) and memory (LTM) requires new gene expression, but the molecular mechanisms that underlie these processes are not fully understood. Phosphorylation of… Expand
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
- Mauro Costa-Mattioli, D. Gobert, +15 authors N. Sonenberg
- Biology, Medicine
- Nature
- 25 August 2005
Studies on various forms of synaptic plasticity have shown a link between messenger RNA translation, learning and memory. Like memory, synaptic plasticity includes an early phase that depends on… Expand
Characterization of Fear Memory Reconsolidation
- Sevil Duvarci, K. Nader
- Psychology, Medicine
- The Journal of Neuroscience
- 20 October 2004
Reactivation of consolidated memories returns them to a protein synthesis-dependent state. One interpretation of these findings is that the memory reconsolidates after use. Two alternative… Expand
NMDA receptors are critical for unleashing consolidated auditory fear memories
- Cyrinne Ben Mamou, Karine Gamache, K. Nader
- Psychology, Medicine
- Nature Neuroscience
- 24 September 2006
Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor… Expand
Autism-related deficits via dysregulated eIF4E-dependent translational control
- C. Gkogkas, A. Khoutorsky, +13 authors N. Sonenberg
- Biology, Medicine
- Nature
- 17 January 2013
Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is strongly… Expand