• Publications
  • Influence
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
TLDR
It is shown that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning.
Memory traces unbound
  • K. Nader
  • Psychology, Biology
    Trends in Neurosciences
  • 1 February 2003
A single standard for memory: the case for reconsolidation
TLDR
It is established that the same operational definitions and types of evidence underpin the deduction of both reconsolidation and consolidation, thus validating the extrapolation that post-retrieval memory plasticity reflects processes akin to those that stabilized the memory following acquisition.
Reply — reconsolidation: The labile nature of consolidation theory
TLDR
It is argued that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories, opening up a new dimension in the study of memory consolidation.
Pharmacological brake-release of mRNA translation enhances cognitive memory
TLDR
A small molecule is identified, named ISRIB, that potently reverses the effects of eIF2α phosphorylation and promises to contribute to the understanding and treatment of cognitive disorders.
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
TLDR
Findings indicate that PKMζ maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention.
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
TLDR
This study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway.
...
...