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Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.
Sildenafil was the first selective inhibitor of phosphodiesterase-5 (PDE5) to be widely used for treating erectile dysfunction. Many recent studies have investigated the cardioprotective role ofExpand
Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury
Dapagliflozin, a new type of drug used to treat diabetes mellitus (DM), is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Although some studies showed that SGLT2 inhibition attenuated reactiveExpand
Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity.
Sildenafil is the first commercially available selective inhibitor of phosphodiesterase-5 (PDE5) and is widely used for the treatment of erectile dysfunction. In recent years, investigations of theExpand
Pretreatment with the tumor nerosis factor-alpha blocker etanercept attenuated ischemia-reperfusion renal injury.
INTRODUCTION Tumor necrosis factor (TNF)-alpha mediates inflammation and apoptosis in ischemia-reperfusion (IR) injury of the kidneys. Etanercept, a soluble TNF-alpha receptor, has shownExpand
Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice.
PURPOSE Renin-angiotensin system activation is involved in inflammation and fibrosis in the kidney. Aliskiren, a direct renin inhibitor, decreases renin-angiotensin system activation, includingExpand
Overhydration measured by bioimpedance analysis and the survival of patients on maintenance hemodialysis: a single-center study
Background Bioimpedance analysis (BIA) helps measuring the constituents of the body noninvasively. Prior studies suggest that BIA-guided fluid assessment helps to predict survival in dialysisExpand
C-Phycocyanin Attenuates Cisplatin-Induced Nephrotoxicity in Mice
Although cisplatin is a highly effective antineoplastic agent, nephrotoxicity is its major clinical problem. Recently, it was reported that Spirulina, a blue-green algae, has potent antioxidantExpand
ERK phosphorylation plays an important role in the protection afforded by hypothermia against renal ischemia‐reperfusion injury
BACKGROUND Although hypothermia attenuates the renal injury induced by ischemia‐reperfusion, the detailed molecular pathway(s) involved remains unknown. ERK phosphorylation is known to protectExpand
The Clinicopathologic Significance of Endothelial Tubuloreticular Inclusions in Glomerular Diseases
Abstract Background: The presence of tubuloreticular inclusions (TRIs) in endothelial cells (ECs) always evokes suspicion of an association with underlying viral infections or autoimmune diseases.Expand
A Case of Membranous Glomerulonephritis with Superimposed Anti-Neutrophil Cytoplasmic Antibody-Associated Rapidly Progressive Crescentic Glomerulonephritis
Idiopathic membranous glomerulonephritis (IMGN) is commonly diagnosed in adults with proteinuria. Rapid deterioration of renal function is a rare complication of IMGN, except when accompanied byExpand