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Impact of arrhythmogenic calmodulin variants on small conductance Ca2+‐activated K+ (SK3) channels
TLDR
It is found that the arrhythmogenic CaM variants CaMN54I, CaMD96V, Ca MD130G, and CaMF142L significantly down‐regulate the SK3 channel current, but with distinct mechanism. Expand
Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays.
TLDR
A noreremophilane is discovered that has strong anti-angiogenic effects on the developing zebrafish embryos as well as on tumor-induced angiogenesis in a zebra fish xenograft model. Expand
Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems.
TLDR
It is validated that CDCA enhances angiogenesis by increasing the expression of vascular growth factor receptors (VEGFR1 and VEGFR2) and matrix metalloproteinases (MMP9) and by decreasing the expressionof adhesion protein vascular endothelial cadherin (VE-cadherin). Expand
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
TLDR
IKCa inhibition by AP14145 selectively increases atrial repolarization, whereas IKr inhibition by dofetilide and ondansetron increases ventricular repolarized to a larger extent than atrialRepolarization. Expand
Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man
TLDR
AP30663 is a novel negative allosteric modulator of KCa2 channels that concentration-dependently prolonged rodent atrial refractoriness with minor effects on the QT-interval and these properties support continued development of AP30663 for treatment of AF in man. Expand
Adsorption and corrosion inhibition performance of Tunbergia fragrans extract on mild steel in acid medium
Abstract The present study describes the application of Tunbergia fragrans extract for inhibition of mild steel corrosion in hydrochloric acid medium. At first the inhibitor was extracted from theExpand