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Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.
Many peptide hormones are produced from larger precursors by endoproteolysis at pairs of basic amino acids (e.g. Lys-Arg and Arg-Arg) within the regulated secretory pathway in endocrine cells.Expand
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Protein kinase C inhibitors eliminate hippocampal long-term potentiation
Recent findings suggest that protein kinase C (PKC) regulates the persistence of long-term potentiation (LTP). To test the hypothesis that PKC inhibition would decrease persistence of potentiation weExpand
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Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.
Micromolar concentrations of cis-fatty acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of cis-fatty acid andExpand
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Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.
Protein kinase C has been shown to be a phospholipid/Ca2+-dependent enzyme activated by diacylglycerol (Nishizuka, Y. (1984) Nature 308, 693-697; Nishizuka, Y. (1984) Science 225, 1365-1370). We haveExpand
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Regulation of protein kinase C activity by cooperative interaction of Zn2+ and Ca2+.
cis-Fatty acids such as oleic acid or linoleic acid have been previously shown to induce full activation of protein kinase C in the absence of Ca2+ and phospholipids (Murakami, K., and Routtenberg,Expand
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Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells.
Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif. WeExpand
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Dietary cis-fatty acids that increase protein F1 phosphorylation enhance spatial memory
Activation of protein kinase C (PKC) facilitates long-term potentiation (LTP), a model of memory, and increases its substrate protein F1 (aka GAP43) phosphorylation in direct relation to synapticExpand
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Effects of cis-fatty acid on protein kinase C activation and protein phosphorylation in the hippocampus.
  • S. G. Chen, K. Murakami
  • Chemistry, Medicine
  • Journal of pharmaceutical science and technology…
  • 1 March 1994
Parenteral or dietary lipids have been shown to alter the acyl composition of tissue lipids effectively. It has been suggested that the changes in the acyl composition would modulate physiologicalExpand
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In vitro biosynthesis of human renin and identification of plasma inactive renin as an activation intermediate.
The biosynthesis and post-translational modifications, including proteolytic processing and core glycosylation, of the human renin precursor have been studied in vitro in a cell-free system. For thisExpand
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Native form of renin in the kidney.
Renin (EC 3.4.99.19) has been observed to exist in a high molecular weight (Mr greater than 50,000) and a low molecular weight from (Mr approximately 42,000) in various tissues. Little is knownExpand
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