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Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine
Self-biting (SB) is an unusual behavioral effect of high doses of certain amphetamine-like drugs in rats. This bizarre behavior has received little attention, perhaps because the high doses of drugExpand
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Another look at amphetamine-induced stereotyped locomotor activity in rats using a new statistic to measure locomotor stereotypy
AbstractRat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of aExpand
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In vivo voltammetric evidence of production of uric acid by rat caudate
Linear sweep in vivo voltammetry with carbon paste electrodes records a prominent peak at about 340 mV in the anterior caudate of rat brain. This peak is increased by microinfusion of uric acid orExpand
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Pharmacologic control of pemoline induced self-injurious behavior in rats
Administration of oral Pemoline produces long lasting amphetamine-type stereotyped behavior and persistent self-biting behavior in rats. The effects of haloperidol, pimozide, diazepam, and serotoninExpand
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Pemoline-induced self-biting in rats and self-mutilation in the deLange syndrome
  • K. Mueller, S. Hsiao
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • 1 November 1980
Self-mutilation in humans occasionally accompanies physiological disorders such as the deLange syndrome. If pemoline-induced self-biting is behaviorally similar to self-mutilation in the deLangeExpand
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Time course of amphetamine-induced locomotor stereotypy in an open field
AbstractGamma ( $$\hat \gamma$$ ) is a recently proposed statistic that quantifies and describes the repetitive patterns of locomotion (locomotor stereotypy) exhibited by amphetamine-treated rats inExpand
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Effects of haloperidol on amphetamine-induced increases in ascorbic acid and uric acid as determined by voltammetry in vivo
Amphetamine produces dramatic changes in extracellular ascorbic acid (AA) and uric acid (UA) in rat caudate; the origin of extracellular AA and UA is being widely investigated. In this study, linearExpand
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The effects of amphetamine and pilocarpine on the release of ascorbic and uric acid in several rat brain areas
Linear sweep voltammetry was used to investigate the effects of amphetamine (which enhances the release of dopamine) and/or pilocarpine (a cholinergic agonist) on the release of ascorbic acid andExpand
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Repeated pemoline produces self-injurious behavior in adult and weanling rats
Self-injurious behavior (SIB) is a serious problem among the mentally handicapped and is often accompanied by other repetitive or stereotyped behaviors. Acute administration of high doses ofExpand
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Modulation of the behavioral effects of amphetamine in rats by clonidine.
Clonidine (0.01, 0.05, 0.5 mg/kg) dramatically reduced the locomotor response to amphetamine (2 mg/kg) in a dose related fashion. In contrast, the same doses of clonidine had no effect on locomotionsExpand
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