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Molecular cloning and characterization of the rat NMDA receptor
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological andExpand
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Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits (NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by molecular screening of a rat brain cDNAExpand
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Mammalian achaete–scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
Whereas vertebrate achaete–scute complex (as‐c) and atonal (ato) homologs are required for neurogenesis, their neuronal determination activities in the central nervous system (CNS) are not yetExpand
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Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
We here report the existence of 6 additional isoforms of the NMDA receptor generated via alternative splicing by molecular analysis of cDNA clones isolated from a rat forebrain cDNA library. TheseExpand
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Labeling Neural Cells Using Adenoviral Gene Transfer of Membrane-Targeted GFP
We describe an experimental system to visualize the soma and processes of mammalian neurons and glia in living and fixed preparations by using a recombinant adenovirus vector to transfer theExpand
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Persistent expression of helix‐loop‐helix factor HES‐1 prevents mammalian neural differentiation in the central nervous system.
In the developing mammalian central nervous system, neural precursor cells present in the ventricular zone determine their fate to become neurons or glial cells, migrate towards the outer layers andExpand
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Alteration of channel activities and gating by mutations of slow ISK potassium channel.
ISK is a small membrane protein consisting of 129-130 amino acid residues with a single putative transmembrane domain and induces a very slow voltage-dependent K+ channel activity in the XenopusExpand
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Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination
The role of inhibitory Golgi cells in cerebellar function was investigated by selectively ablating Golgi cells expressing human interleukin-2 receptor alpha subunit in transgenic mice, using theExpand
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Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors.
Seven in absentia homolog 1A (Siah1A) is a member of the RING-finger-containing E3 ubiquitin ligases and has been shown to bind to the Siah-interacting domain (SID) at the carboxyl-terminal tails ofExpand
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Phosphorylation and Recruitment of Syk by Immunoreceptor Tyrosine-based Activation Motif-based Phosphorylation of Tamalin*
Tamalin is a scaffold protein that forms a multiple protein assembly including metabotropic glutamate receptors (mGluRs) and several postsynaptic and protein-trafficking scaffold proteins in distinctExpand
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