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Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
The purpose of these studies was to determine whether the biological and metastatic behaviors of tumor cells isolated from fresh surgical specimens of human colon carcinomas are influenced by theExpand
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In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
The purpose of these studies was to select and isolate cells with increased liver-metastasizing potential from heterogeneous primary human colon carcinomas (HCCs). Cells derived from a primary HCCExpand
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A role for ferritin in hematopoiesis and the immune system.
Elevated serum ferritin levels have been reported in a number of pathological states. These observations indicate that cells of the immune system can participate in the prevention of potential tissueExpand
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Modulatory effect of antibiotics on cytokine production by human monocytes in vitro.
Some antimicrobial agents have been reported to modify the host immune and inflammatory responses both in vivo and in vitro. Fosfomycin (FOM) and clarithromycin (CAM) have immunomodulatory activityExpand
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Induction of tumoricidal activity of polymorphonuclear leukocytes by a linear beta-1,3-D-glucan and other immunomodulators in murine cells.
The cytotoxic activity of polymorphonuclear leukocytes (PMN) against tumor cells induced in vitro by antitumor immunomodulators was examined by a 51Cr release cytotoxicity assay. Among 28Expand
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Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells.
Orthotopic implantation of human colon carcinoma cells is useful for studying the behavior of metastatic subpopulations. We observed that the parental line and variants of human colon carcinoma KM12Expand
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Immunomodulatory effect of fosfomycin on human B-lymphocyte function.
Fosfomycin (FOM) is an unique antibiotic which is chemically unrelated to any other known antimicrobial agent. Recent investigations have demonstrated that FOM inhibits histamine release fromExpand
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Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro.
The effect of three macrolide antibiotics, midecamycin acetate, josamycin, and clarithromycin, on human T-cell function was investigated in vitro. Midecamycin acetate and josamycin suppressed theExpand
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Host-mediated therapeutic effects produced by appropriately timed administration of bleomycin on a rat fibrosarcoma.
The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect wasExpand
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Vitamin D receptor agonists: opportunities and challenges in drug discovery.
1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is an important hormone that regulates metabolism of calcium and phosphorus in small intestine, kidney, and bone, and its physiological action is expressedExpand
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