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Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients
Purpose: Capecitabine (Xeloda) is a novel fluoropyrimidine carbamate rationally designed to generate 5-fluorouracil (5-FU) preferentially in tumors. The purpose of this study was to demonstrate theExpand
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Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts.
We have evaluated the antitumor activity of XELOX (a combination therapy of capecitabine (Xeloda) and oxaliplatin) in human colorectal and gastric cancer xenograft models. In human colorectal cancerExpand
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Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B
RANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal and pathological conditions. Previous data have demonstrated that human osteosarcomaExpand
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Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS.
Erlotinib is used as a standard treatment for recurrent advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutations in NSCLC have been shown to be a predictiveExpand
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Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
Molecular markers predicting sensitivity to anticancer drugs are important and useful not only for selecting potential responders but also for developing new combinations. InExpand
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Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues.
Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme that metabolizes 5'-deoxy-5-fluorouridine (5'-dFUrd, doxifluridine), an intermediate metabolite of capecitabine, to the active drugExpand
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Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models
PurposeTo clarify the antitumor activity of trastuzumab and its potential as an effective treatment for gastric cancer patients.MethodsLevels of HER2 expression in tumor tissues of gastric cancerExpand
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Apoptosis in Ca2 +  reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF‐κB activation
We previously reported that incubation of cultured astrocytes in Ca2 + ‐containing medium after exposure to Ca2 + ‐free medium caused Ca2 +  influx followed by delayed cell death. Here, we studiedExpand
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Establishment and characterization of cachexia‐inducing and ‐non‐inducing clones of murine colon 26 carcinoma
To investigate the mechanism causing cachexia and its association with shorter patient survival, we cloned weight‐loss‐inducing and ‐non‐inducing sublines of murine colon 26 carcinoma (colon 26). OneExpand
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Murine interleukin‐12 prevents the development of cancer cachexia in a murine model
Murine colon 26 carcinoma causes cachexia even when the tumor burden is small. In this tumor model, murine IL‐12 suppressed the induction of cancer cachexia and also inhibited tumor growth. IL‐12Expand
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