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A PhoQ/P‐regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides
TLDR
This work demonstrates that LPS, a major contributor of bacterial interactions with mammalian cells, is also subject to regulation by sRNAs, and is shown to regulate many outer membrane proteins. Expand
Competition among Hfq‐binding small RNAs in Escherichia coli
TLDR
It is found that deletion of the gene for an expressed and particularly effective competitor sRNA improved the regulation of genes by other sRNAs, suggesting that Hfq is limiting during normal growth conditions, and support the existence of a hierarchy of sRNA competition for HfQ, modulating the function of some s RNAs. Expand
Complex transcriptional and post‐transcriptional regulation of an enzyme for lipopolysaccharide modification
TLDR
In vitro transcription and the behaviour of transcriptional and translational fusions demonstrate that Sigma E acts directly at the level of transcription initiation for eptB, from the same start point as Sigma 70, and suggest that when Sigma E is active, synthesis of EptB transcript outstrips MgrR‐dependent degradation. Expand
The BvgAS Regulon of Bordetella pertussis
TLDR
The first RNA-seq analysis of the BvgAS regulon in B. pertussis is reported, revealing that more than 550 genes are regulated by BVGAS and showing for the first time that genes for multiple and varied metabolic pathways are significantly upregulated in the B.pertussis Bvg(−) mode. Expand
Regulation of Excision Genes of the Bacteroides Conjugative Transposon CTnDOT
TLDR
The results support the hypothesis that RteC acts as a DNA-binding protein that binds upstream of the orf2c promoter and is responsible for tetracycline-regulated transcriptional regulation of theorf1c operon. Expand
Characterization of Cryptic Plasmid of Multidrug-resistant Staphylococcus aureus SA2
TLDR
The 2.4-kb cryptic plasmid of multidrug-resistant Staphylococcus aureus SA2 was characterized by complete nucleotide sequencing and homology comparison and showed mediated resistance to ethidium bromide and quaternary ammonium compounds. Expand
Unexpected effect of a Bacteroides conjugative transposon, CTnDOT, on chromosomal gene expression in its bacterial host
TLDR
The results show that regulatory genes on an incoming mobile element can have multiple effects on its new host, including the activation of previously non‐transmissible elements. Expand
The human intestinal tract – a hotbed of resistance gene transfer? Part II
TLDR
The evidence that antibiotic resistance genes are, in fact, being transferred among bacteria in the colon is summarized and the how and why investigators are trying to determine what conjugative elements mediate this transfer is explored. Expand
Tetracycline-Associated Transcriptional Regulation of Transfer Genes of the Bacteroides Conjugative Transposon CTnDOT
TLDR
The complex regulatory system that controls and links the expression of CTnDOT excision and transfer genes may be designed to ensure stable maintenance of CTmDOT in nature by reducing the fitness toll it takes on the cell that harbors it. Expand
Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes
TLDR
It is suggested that the presence of nonphosphorylated BvgA down-regulates Pfim3 activity when phosphorylatedBvgA is present and may allow the bacterium to quickly adapt to the loss of inducing conditions by rapidly eliminating Pfim 3 activation once the signal for BVGA phosphorylation is removed. Expand
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