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A G Protein–Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination
It is proposed that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination in zebrafish.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation
- A. Mogha, Andrew E. Benesh, +4 authors K. Monk
- Biology, MedicineThe Journal of Neuroscience
- 13 November 2013
A model in which Gpr126 functions in SCs for proper development and myelination is supported and evidence that these functions are mediated via G-protein-signaling pathways is provided.
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
It is shown that homozygous Nf1 mutant (Nf1-/-) Schwann cells secrete Kit ligand (KitL), which stimulates mast cell migration, and that N f1+/- mast cells are hypermotile in response to KitL, which links hyperactivation of the Ras-class IA-PI3K-Rac2 pathway to increased Nf 1+/-mast cell migration.
A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.
It is shown that a short peptide sequence within the ectodomain of two aGPCRs functions as a tethered agonist and may prompt the development of specific ligands for this currently untargeted GPCR family.
The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells.
- Yelena B. Wetherill, C. Petre, K. Monk, A. Puga, K. Knudsen
- Biology, MedicineMolecular cancer therapeutics
- 1 May 2002
It is demonstrated that bisphenol A (BPA), a polycarbonate plastic monomer and established xenoestrogen, initiates androgen-independent proliferation in human prostatic adenocarcinoma cells and implicate BPA as an inappropriate mitogen for prostatic-refractory tumors and provide the impetus to study the consequence of BPA exposure on prostate cancer.
Gpr126 is essential for peripheral nerve development and myelination in mammals
Gpr126 is required for Schwann cell myelination in mammals, and new roles for Gpr126 are defined in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium.
New insights on schwann cell development
Both seminal discoveries and recent advances in understanding of the molecular mechanisms that drive Schwann cell development and myelination are discussed, with a focus on cell–cell and cell–matrix signaling events.
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
It is shown that the cAMP concentration in sciatic nerves from PrPC-deficient mice is reduced, suggesting that PrPC acts via a G protein-coupled receptor (GPCR) and promotes myelin homeostasis through flexible tail-mediated Gpr126 agonism.
The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211
GPR126 has domain-specific functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas the CTF promotes wrapping through cAMP elevation, and this work suggests a model in which Laminin-211 mediates GPR126-induced cAMP levels to control early and late stages of SC development.