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The facilitative glucose transporter GLUT3: 20 years of distinction.
The objective of this review is to discuss the properties and tissue and cellular localization of GLUT3 as well as the features of expression, function, and regulation that distinguish it from the rest of its family and make it uniquely suited as the mediator of glucose delivery to these specific cells. Expand
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
The recent identification of several additional members of the family of sugar transport facilitators (gene symbol SLC2A, protein symbol GLUT) has created a heterogeneous and, in part, confusingExpand
Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients.
Large epidemiologic studies are needed to further study the association between BWS and ART and the culture media could be implicated as a common factor among the children with BWS conceived after ART. Expand
Identification and Characterization of Human Glucose Transporter-like Protein-9 (GLUT9)
Using heterologous expression of GLUT9 in Xenopus oocytes,GLUT9 appears to be a functional isoform with low affinity for deoxyglucose and was not inhibited by cytochalasin B, indicating a similar behavior of GLut9 compared with GLUT5. Expand
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.
These findings suggest maternal obesity has adverse effects as early as the oocyte and preimplantation embryo stage and that these effects may contribute to lasting morbidity in offspring, underscoring the importance of optimal maternal weight and nutrition before conception. Expand
SLC2A9 Is a High-Capacity Urate Transporter in Humans
Evidence is provided that SLC2A9 splice variants act as high-capacity urate transporters and is one of the first functional characterisations of findings from genome-wide association scans. Expand
High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects
The results suggest that reproductive complications in obese females are, at least in part, from oocyte maternal effects, which is consistent with IVF studies where the increased pregnancy failure rate in obese women returns to the normal rate if donor oocytes are used instead of autologous oocytes. Expand
GATA4 regulates Sertoli cell function and fertility in adult male mice
The premise that GATA4 is a key transcriptional regulator of Sertoli cell function in adult mice is supported, and RT-PCR analysis of cKO testes showed decreased expression of germ cell markers and increased expression of testicular injury markers. Expand
Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.
Both models of maternal hyperglycemia and hypoinsulinemia may have a detrimental effect on oocyte maturation and development as detailed by the smaller sizes of oocytes and developing ovarian follicles, the lowered percentage reaching germinal vesicle breakdown, and the greater amount of apoptosis. Expand
Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases.
A brief review of studies to date of miRNAs in maternal circulation and placental tissue in human focuses on some new and interesting findings of diagnostic potential forMiRNAs as biomarkers for pregnancy-specific diseases. Expand