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Oxysterols are substrates for cholesterol sulfotransferase Published, JLR Papers in Press, March 8, 2007.
TLDR
It is established that the steroid/sterol sulfotransferase SULT2B1b, known to efficiently sulfonate cholesterol, also effectively sulfonates a variety of oxysterols, including 7-KC, and offers a potential pathway for modulating in vivo the injurious effects of these compounds.
Derivatization of thiol-containing compounds.
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[S]
TLDR
Using RNA-Seq technology, a cortisol-inducible (∼1,000-fold) operon (desABCD) encoding at least one enzyme involved in anaerobic side-chain cleavage is identified andylogenetic analysis suggests this operon is rare in nature and the desC gene evolved from a gene encoding threonine dehydrogenase.
Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
TLDR
SIK3 is a novel energy regulator that modulates cholesterol and bile acid metabolism by coupling with retinoid metabolism, and may alter the size of energy storage in mice.
Quantitative Determination of Pregnenolone 3-Sulfate in Rat Brains Using Liquid Chromatography/ Electrospray Ionization-Mass Spectrometry
TLDR
This method was applied to the quantitative determination of this steroid in the brains of Wistar strain rats, most of which showed a much lower amount than that previously reported.
Enzymatic hydrolysis of the conjugate of vitamin D and related compounds.
Characterization of non-enzymatic acylation of amino or thiol groups of bionucleophiles by the acyl-adenylate or acyl-CoA thioester of cholic acid
TLDR
Differences in the reactivity ofCA-AMP as compared with that of CA-CoA towards amino and thiol groups may be attributed to the electrophilicity of the carbonyl carbon of these acyl-linked cholic acid metabolites and the nucleophilicity in the bionucleophiles that were studied.
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